ID   A0A2Y9EQM5_PHYMC        Unreviewed;       833 AA.
AC   A0A2Y9EQM5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Ventricular zone-expressed PH domain-containing protein homolog 1 isoform X1 {ECO:0000313|RefSeq:XP_007106946.2};
GN   Name=VEPH1 {ECO:0000313|RefSeq:XP_007106946.2};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007106946.2};
RN   [1] {ECO:0000313|RefSeq:XP_007106946.2}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007106946.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the MELT/VEPH family.
CC       {ECO:0000256|ARBA:ARBA00010187}.
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DR   RefSeq; XP_007106946.2; XM_007106884.3.
DR   AlphaFoldDB; A0A2Y9EQM5; -.
DR   STRING; 9755.ENSPCTP00005005333; -.
DR   Ensembl; ENSPCTT00005005868; ENSPCTP00005005333; ENSPCTG00005003733.
DR   InParanoid; A0A2Y9EQM5; -.
DR   OrthoDB; 2875551at2759; -.
DR   Proteomes; UP000248484; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; IEA:Ensembl.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   CDD; cd01264; PH_MELT_VEPH1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039888; Melted-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21630:SF10; VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1; 1.
DR   PANTHER; PTHR21630; VEPH-A/MELTED; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          716..819
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          460..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  94834 MW;  901E3FCAECBA4AF1 CRC64;
     MHQLFRLVLG QKDLSRAGDL FSLDDSEIED SLTEALEQIK IISSSSDYQT NNNDQAVVEI
     CITRITTAIR ETESIEKHAK ALVGLWDSCL EHNLRPSGKD EDTPHAKIAS DIMSCILQNY
     NRPPVMALAI PIAVKFLHRG NKELCRNMSN YLSLAAITKA DLLADHTEVI VKSILQGNAM
     LLRVLPAVYD KQPQPINRHL TELLALMSQL EQPEQYHLLR LLHVAAKRKQ PEVVQKCIPF
     LIWHLKDSTH NDVILSILIE IAGYEPVALN SFLPMLKEIA ERFPYLIGQM ARIYGAVGHV
     DEERARSCLP FLVSQLASME HSFHHILLLE IKSITDTFSS ILGPQSRDIF RMSNSFTAIA
     KLLTRQLETT KARSDRRKPS TEIEFLEKLE EASLTVDENE DHEKLQVKIQ AFEEKINSEG
     NTPGSIRRYS LDQISKEERK DIRFNRSKSL ALHTALTNDL SSEDGEVVES GDTPASISLS
     EIDPLGQGHD RSPFKGDTDG SQLVNSSVSH PSIIHIESEN LPETVKENYQ EETPDTTSRP
     VEYHDKLYLH LKENLSKVKA YAVEMGKKIP VPDQCTIEDS VRSCVAKLFF TCSLKGHYCL
     YSKSSFILIS QEPQPWIQIM FLFQQSLFPE PLSIQSRSVQ FLRALWEKTQ AEGAHSFETA
     MMESTFPQQK DLDQVQLHLE EVRFFDVFGF SEAAGAWQCF MCNNPEKATV VNQDGQPLIE
     GKLKEKQVRW KFIKRWKTRY FTLAGNQLLF QKGKSKDDPD DSPIELSKVQ SVKVVAKKRR
     DRSLPRAFEI FTDNKSYVFK AKDEKNAEEW LQCINVAVAQ AKERESREVT TYL
//