ID A0A2Y9ERD3_PHYMC Unreviewed; 553 AA.
AC A0A2Y9ERD3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Galectin-3-binding protein {ECO:0000256|ARBA:ARBA00019410};
DE AltName: Full=Lectin galactoside-binding soluble 3-binding protein {ECO:0000256|ARBA:ARBA00031798};
GN Name=CANT1 {ECO:0000313|RefSeq:XP_007106758.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007106758.2};
RN [1] {ECO:0000313|RefSeq:XP_007106758.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007106758.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Promotes integrin-mediated cell adhesion. May stimulate host
CC defense against viruses and tumor cells.
CC {ECO:0000256|ARBA:ARBA00024860}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_007106758.2; XM_007106696.4.
DR AlphaFoldDB; A0A2Y9ERD3; -.
DR STRING; 9755.ENSPCTP00005031449; -.
DR InParanoid; A0A2Y9ERD3; -.
DR OrthoDB; 5397373at2759; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR24410:SF16; GALECTIN-3-BINDING PROTEIN; 1.
DR PANTHER; PTHR24410; HL07962P-RELATED; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00530; SRCR; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00202; SR; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00420; SRCR_1; 1.
DR PROSITE; PS50287; SRCR_2; 1.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..553
FT /note="Galectin-3-binding protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015841121"
FT DOMAIN 24..124
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 153..221
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DISULFID 49..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 62..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 93..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 553 AA; 61873 MW; FE4A27D14F3EE102 CRC64;
MAPLRLLWMW LLVAGIQGVK DGDMRLADGD AANEGRVEIY YSGQWGTVCD NLWDLTDASV
VCRALGFRNA TEALGRATFG PGRGPVLLDK VQCTGTEPSL ASCTFPGWMK SHCSHDKDAG
VICTNETRGI HTFDLSSELP AALEQIFESQ KGCDLFITVK TKEEDELGIC AHKLILSTNP
EAHGLWKEPR SRVTMEVDTE CVPVVRDFIK YLYSRRIDVS LSSVRCLHKL ASAYGAKRLQ
SYCGHLFAIL LPEDPSFRTP LDLYAYALAS RDPVLEEICV QFLAWNFGAL TQAEAWPNVP
TALLRDLLSR SELVTPSELA VLLALDEWSQ ERRISRGEVE GLLERVRFPM ILPRDLFTLQ
FNLSLYWSHK ALFQKKMLQA LEFHTVPFEL LAQYRGLNLT EDIYQPRLYT SPTWSASVMG
SDYDRYRSFQ TPQHPSFLFQ ASSVSWSFVY LPTIQSCWNY GFSCSSDDPP LLGLSKSSYS
NPTIGYENKA LMLCGGNFVA DVTNFEGWKA LIPGALGTNS SRRASFFPCP AGSFSSFQVA
IRPFYLTNCT GVD
//
