ID   A0A2Y9ETD7_PHYMC        Unreviewed;       465 AA.
AC   A0A2Y9ETD7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Clusterin {ECO:0000256|RuleBase:RU000629};
GN   Name=CLUL1 {ECO:0000313|RefSeq:XP_007107906.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007107906.1};
RN   [1] {ECO:0000313|RefSeq:XP_007107906.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007107906.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the clusterin family.
CC       {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR   RefSeq; XP_007107906.1; XM_007107844.1.
DR   AlphaFoldDB; A0A2Y9ETD7; -.
DR   STRING; 9755.ENSPCTP00005025983; -.
DR   Ensembl; ENSPCTT00005028606; ENSPCTP00005025983; ENSPCTG00005018544.
DR   GeneID; 102985704; -.
DR   KEGG; pcad:102985704; -.
DR   CTD; 27098; -.
DR   InParanoid; A0A2Y9ETD7; -.
DR   OrthoDB; 5320180at2759; -.
DR   Proteomes; UP000248484; Chromosome 19.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000753; Clusterin-like.
DR   InterPro; IPR016015; Clusterin_C.
DR   InterPro; IPR016014; Clusterin_N.
DR   PANTHER; PTHR10970; CLUSTERIN; 1.
DR   PANTHER; PTHR10970:SF2; CLUSTERIN-LIKE PROTEIN 1; 1.
DR   Pfam; PF01093; Clusterin; 1.
DR   SMART; SM00035; CLa; 1.
DR   SMART; SM00030; CLb; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..465
FT                   /note="Clusterin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016072518"
FT   DOMAIN          26..237
FT                   /note="Clusterin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00030"
FT   DOMAIN          238..459
FT                   /note="Clusterin C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00035"
FT   COILED          63..104
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   465 AA;  54363 MW;  C2A5C2CF1524D2CC CRC64;
     MKLPLLVFIA YLLWLKDCHC APTWKDKTAI HGDLKGFSKA GKIDIDEEVK KALTGMKQMK
     ILMERREEEH SNLMRTLKKC REEKQEALKL MNEVQEHLEE EERLCQVSLT GSWDECKSCL
     ESNCMRFYTT CQNSWSSMKN KLEHFFRKIY QFLFPFHEDN EKDLPIGEKF VEEDAQLTQI
     ENMFSQLTVD VGFLYNRSFD VFKQMQQEFD QAFQSYFMSD TDFMEPYFFP AFSKEPAKKA
     HPVQSWDIPS FFQLFCNFSL SIYQSVSATV TEMLKAIEDL SKQDKDSAHG GLSRTALPVR
     GRGLCGELRQ NSSECFQFHA RCQKCQDYLQ EDCPDVPKLY TKVDEALELV NISNQQYAQV
     LQMTQHHLED TTYLMEKMRE QFGWVTELAN QTLGTENIFN FIKVVPGVRE GNFPKQDVTM
     RDVSILPSPN FTLTITHEES AESSNFISYM LAKAVQHFKE HFKSW
//