ID A0A2Y9EVR1_PHYMC Unreviewed; 393 AA.
AC A0A2Y9EVR1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Fibulin-7 isoform X2 {ECO:0000313|RefSeq:XP_007109646.1};
GN Name=FBLN7 {ECO:0000313|RefSeq:XP_007109646.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007109646.1};
RN [1] {ECO:0000313|RefSeq:XP_007109646.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007109646.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_007109646.1; XM_007109584.1.
DR AlphaFoldDB; A0A2Y9EVR1; -.
DR GeneID; 102982785; -.
DR CTD; 129804; -.
DR OrthoDB; 19806at2759; -.
DR Proteomes; UP000248484; Chromosome 12.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF94; FIBULIN-7; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00084; Sushi; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..393
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015888651"
FT DOMAIN 79..136
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 136..172
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 107..134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 162..171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 393 AA; 43036 MW; 83C5E1615513D3F7 CRC64;
MVPNCPRALF LLLLFLACPE SRASQNCLNK QQLLSAIRQL QQLLKGQETR FAEGVRHMKS
RLVALQSSVS RAGPDTPPVS CPALSTPPDG RKFGSKYLVD HEVHFTCNAG FRLVGPSSVV
CLPNGTWTGE QPRCRDISEC SSQPCQNGGT CVEGVNQYKC ICPPGRTGSR CQHQAQTDVN
ECELYGQEGR SRLCMHACVN TPGSYRCACP SGYRTLADGK SCEDVDECVS PQHVCPRGTV
CVNTGGGFQC VSPECPEGSG NVSYVKTSPF QCERNPCPMD SRPCRHMPKT ISFHYLSLPS
NLKTPITLFR MATASAPGRP GPNSLRFGIV GENSRGHFVM QRSDRQTGEL ILVQTLEGPQ
TLEVDVDMSE YLDRSFQANH VSKVTIFVSP YDF
//
