ID A0A2Y9EWU6_PHYMC Unreviewed; 213 AA.
AC A0A2Y9EWU6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Apolipoprotein D {ECO:0000256|ARBA:ARBA00019890};
GN Name=APOD {ECO:0000313|RefSeq:XP_028348339.1,
GN ECO:0000313|RefSeq:XP_054940616.1, ECO:0000313|RefSeq:XP_054940619.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028348339.1};
RN [1] {ECO:0000313|RefSeq:XP_028348339.1, ECO:0000313|RefSeq:XP_054940616.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028348339.1,
RC ECO:0000313|RefSeq:XP_054940616.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000256|ARBA:ARBA00006889, ECO:0000256|RuleBase:RU003695}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007110569.1; XM_007110507.1.
DR RefSeq; XP_007110570.1; XM_007110508.1.
DR RefSeq; XP_007110571.1; XM_007110509.1.
DR RefSeq; XP_028348339.1; XM_028492538.2.
DR RefSeq; XP_054940616.1; XM_055084641.1.
DR RefSeq; XP_054940619.1; XM_055084644.1.
DR AlphaFoldDB; A0A2Y9EWU6; -.
DR STRING; 9755.ENSPCTP00005000654; -.
DR Ensembl; ENSPCTT00005000735; ENSPCTP00005000654; ENSPCTG00005000541.
DR InParanoid; A0A2Y9EWU6; -.
DR OrthoDB; 3783962at2759; -.
DR Proteomes; UP000248484; Chromosome 1.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0051895; P:negative regulation of focal adhesion assembly; IEA:Ensembl.
DR GO; GO:0060588; P:negative regulation of lipoprotein lipid oxidation; IEA:Ensembl.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR GO; GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:2000098; P:negative regulation of smooth muscle cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:2000405; P:negative regulation of T cell migration; IEA:Ensembl.
DR GO; GO:0000302; P:response to reactive oxygen species; IEA:Ensembl.
DR GO; GO:0042246; P:tissue regeneration; IEA:InterPro.
DR CDD; cd19437; lipocalin_apoD-like; 1.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR026222; ApoD_vertbrte.
DR InterPro; IPR002969; ApolipopD.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR10612; APOLIPOPROTEIN D; 1.
DR PANTHER; PTHR10612:SF34; APOLIPOPROTEIN D; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR02058; APODVERTBRTE.
DR PRINTS; PR01219; APOLIPOPROTD.
DR PRINTS; PR00179; LIPOCALIN.
DR SUPFAM; SSF50814; Lipocalins; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 3: Inferred from homology;
KW Pyrrolidone carboxylic acid {ECO:0000256|ARBA:ARBA00023283};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..44
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 45..213
FT /note="Apolipoprotein D"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041069062"
FT DOMAIN 68..206
FT /note="Lipocalin/cytosolic fatty-acid binding"
FT /evidence="ECO:0000259|Pfam:PF00061"
SQ SEQUENCE 213 AA; 24193 MW; B74A9092575CBB3D CRC64;
MILHVETAFI WIKKVHLQPP SSKMVPALLL LLPALAGLFG AAEGQAFHLG KCPNPPVQEN
FDVNKYLGRW YEIEKIPVSF EKGSCIQANY SLMENGNIKV INKELRADGT VSQIEGEATQ
ENITEPAKLG VKFFWFMPSA PYWVLATDYE NYALVYSCTT IIWLFHMDHV WLLGRNPYLP
PETVTYLKDI LTSNNIDIEK ITVTDQVNCP EFL
//
