ID A0A2Y9EY59_PHYMC Unreviewed; 340 AA.
AC A0A2Y9EY59;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Carbonic anhydrase {ECO:0000256|RuleBase:RU367011};
DE EC=4.2.1.1 {ECO:0000256|RuleBase:RU367011};
GN Name=CA5A {ECO:0000313|RefSeq:XP_007111347.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007111347.2};
RN [1] {ECO:0000313|RefSeq:XP_007111347.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007111347.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Reversible hydration of carbon dioxide.
CC {ECO:0000256|RuleBase:RU367011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544; EC=4.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000943,
CC ECO:0000256|RuleBase:RU367011};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU367011};
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718, ECO:0000256|RuleBase:RU367011}.
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DR RefSeq; XP_007111347.2; XM_007111285.2.
DR AlphaFoldDB; A0A2Y9EY59; -.
DR STRING; 9755.ENSPCTP00005007558; -.
DR KEGG; pcad:102982894; -.
DR InParanoid; A0A2Y9EY59; -.
DR OrthoDB; 49814at2759; -.
DR Proteomes; UP000248484; Chromosome 17.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF89; CARBONIC ANHYDRASE 5A, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS00162; ALPHA_CA_1; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU367011};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367011};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367011}.
FT DOMAIN 36..301
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
SQ SEQUENCE 340 AA; 38385 MW; 91B93AA5F3253AFB CRC64;
MLRLLGSGRS HLKSSGLSVL VEQTWEAPRS HPLRLERWCS QGPCAQRKRN DALHALWKGP
ASVPGGARQS PINIRWKDSV YDPRLKPLRV SYDSAACLYV WNTGYVFQVE FDDSTEGSGI
SGGPLENHYR LKQFHFHWGA VNEWGSEHTV DDHVYPAELH LVHWNAVKYP SYAEAVMGED
GLAVVGVFLK LGTRHEALQK LVAVLPDIKH KDARAALGPF QPSCLLPACR DYWTYPGSLT
TPPLSESVTW IIHKKPTEVA QDQLAAFRSL MFSALGEEEK TMVNNYRPLQ PLMKREVRSS
FQPLKTVQDP KFTTSKLTDR TDFNKRKYCF PGFTSCSDGM
//
