ID A0A2Y9EZN0_PHYMC Unreviewed; 509 AA.
AC A0A2Y9EZN0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Nectin-4 isoform X2 {ECO:0000313|RefSeq:XP_007112357.1};
GN Name=NECTIN4 {ECO:0000313|RefSeq:XP_007112357.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007112357.1};
RN [1] {ECO:0000313|RefSeq:XP_007112357.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007112357.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR RefSeq; XP_007112357.1; XM_007112295.3.
DR AlphaFoldDB; A0A2Y9EZN0; -.
DR STRING; 9755.ENSPCTP00005018617; -.
DR Ensembl; ENSPCTT00005020508; ENSPCTP00005018617; ENSPCTG00005013147.
DR GeneID; 102995287; -.
DR KEGG; pcad:102995287; -.
DR CTD; 81607; -.
DR InParanoid; A0A2Y9EZN0; -.
DR OrthoDB; 4235960at2759; -.
DR Proteomes; UP000248484; Unplaced.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd07704; IgC1_2_Nectin-3-4_like; 1.
DR CDD; cd05888; IgV_1_Nectin-4_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR033320; IgC1_2_Nectin-3-4-like.
DR PANTHER; PTHR23277:SF11; NECTIN-4; 1.
DR PANTHER; PTHR23277; NECTIN-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..509
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016110884"
FT TRANSMEM 344..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..143
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 147..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 261..330
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 399..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 509 AA; 55279 MW; C10C3EB8327FFEA1 CRC64;
MPLSLGAEMC GPEAWLLLLL LASFTGRCPA GELETSDLVT VVLGQDAKLP CFYRGDPGEQ
VEQVAWARVD EGEGGQELAL LNSKYGLHVS SAYDGRVEEP PPPRNPLDGA VLLRNAVQAD
EGEYECRVST FPAGSFQARL RLRVLVPPLP SLNPGPALEE GQGLTLAASC TAEGSPAPSV
TWDTEVKGTT SSRSFTHSRS AAVTSEFHLV PSRSMNGQPL TCVVSHPGLL QDQRITHILQ
VAFLAEASVR GLEDQKLWQV GREGAMLKCL SEGQPPPSYN WTRLDGPLPS GVQAEGDTLA
FPPLTTEHRG TYVCHVSNEL SSRDSQVVVD VLDPQDTTGK RVDLVSASVV VVGVIAALLF
CLLVVVVVLM SRYHRRKAQQ MTQKYEEELT LTRENSIRRL HSHHPDPRNQ PEESVGLRAE
GHPDGLKDNS SCSVMSEEAE GRSYSTLTTV REIETQTELL SPGSGRTEEE EDQDEGIKQA
MNHFVQENGT LRAKPTGNGI YINGRGHLV
//
