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Database: UniProt
Entry: A0A2Y9F1E2_PHYMC
LinkDB: A0A2Y9F1E2_PHYMC
Original site: A0A2Y9F1E2_PHYMC 
ID   A0A2Y9F1E2_PHYMC        Unreviewed;       258 AA.
AC   A0A2Y9F1E2;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Insulin-like growth factor-binding protein 4 {ECO:0000256|ARBA:ARBA00013680};
GN   Name=IGFBP4 {ECO:0000313|RefSeq:XP_007112559.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007112559.1};
RN   [1] {ECO:0000313|RefSeq:XP_007112559.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007112559.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and
CC       have been shown to either inhibit or stimulate the growth promoting
CC       effects of the IGFs on cell culture. They alter the interaction of IGFs
CC       with their cell surface receptors. {ECO:0000256|ARBA:ARBA00003811}.
CC   -!- SUBUNIT: Binds IGF2 more than IGF1. {ECO:0000256|ARBA:ARBA00011592}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   RefSeq; XP_007112559.1; XM_007112497.4.
DR   AlphaFoldDB; A0A2Y9F1E2; -.
DR   STRING; 9755.ENSPCTP00005028765; -.
DR   Ensembl; ENSPCTT00005031642; ENSPCTP00005028765; ENSPCTG00005020609.
DR   GeneID; 102980664; -.
DR   KEGG; pcad:102980664; -.
DR   CTD; 3487; -.
DR   InParanoid; A0A2Y9F1E2; -.
DR   OrthoDB; 5394492at2759; -.
DR   Proteomes; UP000248484; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 4.10.40.20; -; 1.
DR   Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR022327; IGFBP-4.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR022321; IGFBP_1-6_chordata.
DR   InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR   PANTHER; PTHR11551:SF7; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 4; 1.
DR   Pfam; PF00219; IGFBP; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   PRINTS; PR01976; IGFBPFAMILY.
DR   PRINTS; PR01980; IGFBPFAMILY4.
DR   SMART; SM00121; IB; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR   PROSITE; PS00222; IGFBP_N_1; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..258
FT                   /note="Insulin-like growth factor-binding protein 4"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016084218"
FT   DOMAIN          23..103
FT                   /note="IGFBP N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51323"
FT   DOMAIN          171..249
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
SQ   SEQUENCE   258 AA;  27958 MW;  8877782CACC87B74 CRC64;
     MLPLCLVAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA
     LGKGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLVHGQGVC MELAEIEAIQ ESLQPSDKDE
     GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS TSGGKMKVIG VPREEARPVP QGSCQSELHR
     ALERLAASQS RTHEDLYIIP IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG
     LEPKGELDCH QLADSFRE
//
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