ID A0A2Y9F2M3_PHYMC Unreviewed; 203 AA.
AC A0A2Y9F2M3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=von Hippel-Lindau disease tumor suppressor isoform X1 {ECO:0000313|RefSeq:XP_007113784.2};
GN Name=VHL {ECO:0000313|RefSeq:XP_007113784.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007113784.2};
RN [1] {ECO:0000313|RefSeq:XP_007113784.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007113784.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VHL family. {ECO:0000256|ARBA:ARBA00010057}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007113784.2; XM_007113722.4.
DR AlphaFoldDB; A0A2Y9F2M3; -.
DR STRING; 9755.ENSPCTP00005010868; -.
DR KEGG; pcad:102997043; -.
DR InParanoid; A0A2Y9F2M3; -.
DR OrthoDB; 2951928at2759; -.
DR Proteomes; UP000248484; Chromosome 18.
DR CDD; cd05468; pVHL; 1.
DR Gene3D; 1.10.750.10; von Hippel-Lindau disease tumour suppressor, alpha domain; 1.
DR Gene3D; 2.60.40.780; von Hippel-Lindau disease tumour suppressor, beta domain; 1.
DR InterPro; IPR024048; VHL_alpha_dom.
DR InterPro; IPR037139; VHL_alpha_dom_sf.
DR InterPro; IPR024053; VHL_beta_dom.
DR InterPro; IPR037140; VHL_beta_dom_sf.
DR InterPro; IPR036208; VHL_sf.
DR InterPro; IPR022772; VHL_tumour_suppress_b/a_dom.
DR PANTHER; PTHR15160:SF1; VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR; 1.
DR PANTHER; PTHR15160; VON HIPPEL-LINDAU PROTEIN; 1.
DR Pfam; PF01847; VHL; 1.
DR Pfam; PF17211; VHL_C; 1.
DR SUPFAM; SSF49468; VHL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 47..128
FT /note="von Hippel-Lindau disease tumour suppressor beta"
FT /evidence="ECO:0000259|Pfam:PF01847"
FT DOMAIN 140..188
FT /note="von Hippel-Lindau disease tumour suppressor alpha"
FT /evidence="ECO:0000259|Pfam:PF17211"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 203 AA; 23189 MW; 8012D506D1B1DE7A CRC64;
MPWRAGNAEE AEAGAEEAGA ECGPEESHPE EPGSQQEMEA GRPRPMLRSV NTREPSQVIF
CNRSPRVVLP VWLNFDGEPQ PYPTLPPGTG RRIHSYRGHL WLFRDAGTSD GLLVNQTELF
VPSLNVDGQP IFANITLPVY TLKERCLQVV RSLVKPEDYR RLDIARSLYE DLEDHPNVWK
DLERLTQEHI ENQRMAEETE DFN
//
