ID A0A2Y9F2W8_PHYMC Unreviewed; 3209 AA.
AC A0A2Y9F2W8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Collagen alpha-3(VI) chain isoform X2 {ECO:0000313|RefSeq:XP_007114153.2};
GN Name=COL6A3 {ECO:0000313|RefSeq:XP_007114153.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007114153.2};
RN [1] {ECO:0000313|RefSeq:XP_007114153.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007114153.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007114153.2; XM_007114091.4.
DR Proteomes; UP000248484; Chromosome 2.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd22629; Kunitz_collagen_alpha3_VI; 1.
DR CDD; cd01481; vWA_collagen_alpha3-VI-like; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 12.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR041900; vWA_collagen_alpha3-VI-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF20; COLLAGEN ALPHA-1(XXI) CHAIN; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00092; VWA; 12.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00131; KU; 1.
DR SMART; SM00327; VWA; 12.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 12.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50234; VWFA; 12.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119,
KW ECO:0000313|RefSeq:XP_007114153.2};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..3209
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015841122"
FT DOMAIN 38..212
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 241..414
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 444..619
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 638..815
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 836..1008
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1028..1204
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1232..1403
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1435..1608
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1638..1811
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1837..2023
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2401..2580
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2618..2814
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 3023..3121
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3144..3194
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 1612..1632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2043..2371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2888..3027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2107..2123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2131..2151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2290..2312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2922..2936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3209 AA; 347395 MW; AC35FA822BF433FB CRC64;
MRKHRHLPLV AIFCLFFSGF SFTHAQQQAD VKNGAAADIM FLVDSSWSIG KEHFQLVQEF
LYDVIKSLAV GENDFRFALV WFNGSPDTEF LLNTYRSKQE VLSHVSNMSY TGGSNQTGKG
LEYVMRNHLT EVAGSRASDG VPQVIVVLTD GHSKDALALP LAELKSADVN VFAIGVEDAD
EGALKETASE PLNVHMFNLE NFTSLHDIVG NLVACVHSSM TPERAGGTET LKDITAQDSA
DIIFLIDGSN NTGSVNFAVI RDFLVNLLER LSVGTQQIQV GVVQYSDEPR TLFSLNSYST
KAQVLDAVKA LGFIGGELAN VGLALDFVLE NHFTRAGGSR VEEGVPQVLV LISAGPSSDE
IRDAVIALKQ ASIFSFGLGA QAAPKAELQH IATNDNLVFT VPEFRSFGDV QEQLLPYIVG
VAQRHIVLQP PTIVTQVIEI NKRDIVFLVD GSSALGLVSF NAIRDFVAKV IQRLEIGQDY
IQVAVAQYAD TVRPEFYFNT YPTKREVVTA VRKMKPMDGS ALYTGSALDF VRNNLFTGAA
GYRAAEGVPK LLVLITGGKS LDEVSQPAQE LKRSSIMAFA IGNKVANRAE LEEIAFDSSL
VFIPAEFRAA PLQGVLPGLL APLRTLSGTT EVHVNKRDII FLLDGSFNVG KTNFPYVRDF
VMNVVNSLDV GSDHIRVGLV QFSDTPVTEF SLNTYQTKAD LLAHLRQLQL KGGLGLNTGA
ALSYVHDEHF TEAGGSRIRD RVPQLLLLFA AGQSEDSYLQ AANALARAGI LTFCVGTSQA
NKAELEQIAF NPSLVYLMDD FSSLPALPQQ LIQPLTTYVS GGVEEVPLAQ PESKRDILFL
FDGSANLVGQ FPAVRDFLYK VIDELDVKPD RTRVAVAQYS DDVRVESRFD EHQSKPEILN
LVKRMKIKTG KALNLGYALD YAQRYIFVKS TGSRVEDGVL QFLVLLVAGR SSDRVDRPAL
NLKQSGVVPF ILQAKNADPA ELEQIVPSPA FILAAESLPK IGDLQAQIVN LLKSVQNGAP
TPVSGEKDVV FLIDGSEGVR NGFPLLKEFV QRVVESLDVG ADRVRVAVVQ YSDRTRPEFY
LNSYMDQQSI VGAIRGLTLL GGPTPNTGAA LDFVLRNILI GSAGSRIAEG VPQLLIVLTA
DRSGDDVRGP SVVLKRGGAV PIGVGIGNAD ITEMQTISLI PDFAVVIPTF RQLGTVQQVI
SERVTQLSRE ELSRLRASVV PPTTPGVGGK RDVVFLIDGS QSASPEFQYI RTLIERLVDY
LDVGFDMTRV AVIQFSEDPR VEFLLNAHSS KDEVQNAVRR LRPKGGRQIN IGGALEYVSR
NIFKRPLGSR IEEGVPQFLV LISSGKSDDE VDEPAVELKQ FGVAPLTIAR NADQEQLVKI
SLSPEYVFSV STFRELPSLE QKLLTPITTL TSEQVQQLLA STRYPPPAVE SDAADIVFLI
DSSDSVRPDG IAHIRDFVSR IVRRLNIGPN KVRIGVVQFS NDVFPEFYLK TYKSQANVLD
AIRRLRFKGG SPLNTGKALE FVARNFFVKS AGSRIEDGVP QHLVLFLGGK SQDDVSRYSQ
VISSSGIVSL GIGDRNIDRM ELQTITNDSR LVFTVREFRE LPNIEERVMN SFGPSKVTPA
PPGVDTPSPS RPETKKADIV FLLDGSINFR RDSFQEVLHF VSEIVDTVYE GGDSIQVGLV
QYNSDPTDEF FLKDFSTKQQ IIDAINKVVY KGGRHANTKV GLEHLRLNHF VPEAGSRLDQ
RVPQIAFVIT GGRSVEDAQE ASLALTQRGV KVFAVGVKNI DSEEVGKIAS NSATAFRVGN
VQELSELSEQ VLETLHDAMH ETLCPGVPDV SKVCNLDVIL GFDGSRDQNI FVAQRSFESK
MDTILNRISQ MQRISCSGSQ LPMVRVSVVA NTPSGPVEAF DFAEYQPELF EKFQNMRTQH
PYVLTADTLK LYQNKFQQAS PDSVKVVIHF TDGVDGDLAD LQRASEQLRQ EGVRALIFVG
LERVSNLEQL MQLEFGRGFM YSRPLRLNLL DLDYELAEQL DNIAEKACCG VPCKCSGQRG
DRGPIGSIGP KGIPGEDGYR GYPGDEGGPG ERGPPGVNGT QGFQGCPGQR GIKGSRGFPG
EKGELGEIGL DGLDGEDGDK GLPGISGEKG NPGRRGDKGP KGDKGERGDV GIRGDPGNSG
QDSQQRGPKG ETGDIGPMGL PGTDGVSGGP GEPGKSGGVG RRGPSGAKGN KGGPGQPGSV
GEQGTRGAQG PPGPTGPPGL IGEQGILGPR GSGGTAGAPG ERGRTGPLGR KGEPGDPGPK
GSVGNRGPRG ETGDDGRDGV GSEGRRGKKG ERGFPGYPGP KGYPGEPGTD GALGPKGIRG
RRGNSGPPGV AGQKGDPGYP GPSGYKGSRG DSMDQCALVQ SIKDKCPCCY GPLECPVFPT
ELAFALDTSE GVTQDTFSRM RDVVLKIVDD LTIAESNCPR GARVAVVTYN NEVTTEIRFA
DSKKKSVLQD KIKNLQVALT SKQQSLETAM SFVARNTFKR VRNGFLMRKV SVFFSNKPTT
ESPQLREAVL KLSDAGITPL FLTSQEDRQL VNALQINNTA VGHALVLPAS GDLTDFLKKV
LTCHVCLDIC NIDPSCGFGS WRPSFRDRRA AGSDVDIDIA FILDSSESTT LFQFNEMRKY
IEYLVQQLDM SPDPKASQHF ARVAVVQHAP YESMGNASVP PVKVEFSLTD YGSKEKLLAF
LGSRMTQLQG TRALGSAIDY TIENIFESAP NPRDLKLVVL MLTGEVKNQQ LEEAQRAILQ
AKCKGYFFVI LGIGRKVNVK ELYSFASEPN DIFFKLMDKS TELNEEPLMR FGRLLPSFIS
SKNAFYLSPD IRKQCDWFQG DQPAKNLVQF GYKQINVPNN VTSSPTSKPV TTAKPVTTTT
KPVTVVNLPT SKPASMRPVA ERPVAGRPMA TKPEAVKSTA TKPEAVKSTA TKPEAVKSTA
TKPEAAKPLA SPVATKPEAT KPEVSKTATV RSAVATRPAA AKPAPARPPA AAKPMAAKPE
APRPQAAKLA ATRPATAKPM VKAPREVHAS EITENSAKLH WERPEPPSPY LYNLTITSAH
DQSPVLKQNL TVTDRVIGGL LPGQTYHVTV ICYLRSQVRA IYQGSFSTKK IQPPPLQTAR
SASSSTINLV VSAERLAGSK TDICKLPKEE GTCRDFILKW YYDSVTESCA RFWYGGCGGN
ENRFDSQDEC EKVCPPVLIK PGVIAAIGT
//
