ID A0A2Y9F3E3_PHYMC Unreviewed; 1097 AA.
AC A0A2Y9F3E3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Protein transport protein Sec24C isoform X2 {ECO:0000313|RefSeq:XP_007114431.1};
GN Name=SEC24C {ECO:0000313|RefSeq:XP_007114431.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007114431.1};
RN [1] {ECO:0000313|RefSeq:XP_007114431.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007114431.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR RefSeq; XP_007114431.1; XM_007114369.4.
DR RefSeq; XP_007114432.1; XM_007114370.1.
DR RefSeq; XP_007114433.1; XM_007114371.1.
DR RefSeq; XP_007114434.1; XM_007114372.1.
DR RefSeq; XP_007114435.1; XM_007114373.1.
DR RefSeq; XP_007114436.1; XM_007114374.1.
DR AlphaFoldDB; A0A2Y9F3E3; -.
DR STRING; 9755.ENSPCTP00005026660; -.
DR Ensembl; ENSPCTT00005029358; ENSPCTP00005026660; ENSPCTG00005019137.
DR GeneID; 102976449; -.
DR KEGG; pcad:102976449; -.
DR CTD; 9632; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000248484; Chromosome 20.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF5; PROTEIN TRANSPORT PROTEIN SEC24C; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 425..463
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 502..746
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 751..834
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 847..946
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 964..1035
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..276
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 118441 MW; 66CF4A2888B3C47A CRC64;
MNVNQSAPPV PPFGQPQPVY LGHHQSSYGG QLGSTTAPTS YGAYNGPVPS YQQTPPPGVS
RAPPSAGAPP ASTAQGPCGQ TAYGQFGQGD VQNGPSSTVQ MQRLPGYQPF GSAILAPVVS
QPAVLQPYGP PPTSAQVTAQ LAGMQISGAV APASPPSGLG YGPPTSLASA SGSFPNSGLY
GSYPQGQAPP LGQAQGHPGA QPPQRSVPLQ ASSFTPPASG GPRMPSMTGP LLPGQSFGGP
PVSQPNHVSS PAPQALPPGT QMTGPPGPPP PPMHSSQQPG YQLQQNGSFG PTRGPQSNYG
SPYPGAAAFG SQPGPPQPLP PKRLDPDAIP SPIQVIEDDR NNRGSEPFVT GVRGQVPPLV
TTNFLVKDQG NASPRYIRCT SYNIPCTSDM AKQAQVPLAA VIKPLARLPP EEASPYVVDH
GESGPLRCNR CKAYMCPFMQ FVEGGRRFQC CFCSCINDVP PQYFQHLDHT GKRVDAYDRP
ELSLGSYEFL ATVDYCKNNK FPSPPAFIFM IDVSYNAIRS GLVRLLCEEL KSLLDFLPRE
GGAEESAIRV GFVTYNKVLH FYNVKSSLAQ PQMMVVSDVG DMFVPLLDGF LVNVNESQAV
ITSLLDQIPE MFADTRETET VFAPVIQAGM EALKAAECAG KLFLFHTSLP IAEAPGKLKN
RDDRKLINTD KEKTLFQPQT GAYQTLAKEC VAQGCCVDLF LFPNQYVDVA TLSVVPQLTG
GSVYKYACFQ VENDQERFLS DLRRDVQKVV GFDAVMRVRT STGIRAVDFF GAFYMNNTTD
VELAGLDGDK TVTVEFKHDD RLNEENGALL QCALLYTSCA GQRRLRIHNL ALNCCTQLAD
LYRNCETDTL INYMAKFAYR GVLNSPVKTV RDTLITQCAQ ILACYRKNCA SPSSAGQLIL
PECMKLLPVY LNCVLKSDVL QPGAEVTTDD RAYVRQLVTS MDVAETNVFF YPRLLPLTKS
PIENTTEPPA VRASEERLSN GDIYLLENGL NLFLWVGAGV QQGVVQSLFG VSSFSQITSG
LSVLPVLDNL LSKKVQGLID SLRAQRSRYM KLIVVKQEDK LETVFKHFLV EDKSLSGGAS
YVDFLCHMHK EIRQLLS
//
