ID A0A2Y9F3V6_PHYMC Unreviewed; 542 AA.
AC A0A2Y9F3V6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cationic amino acid transporter 3 isoform X3 {ECO:0000313|RefSeq:XP_007114521.1};
GN Name=SLC7A3 {ECO:0000313|RefSeq:XP_007114521.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007114521.1};
RN [1] {ECO:0000313|RefSeq:XP_007114521.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007114521.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_007114521.1; XM_007114459.3.
DR AlphaFoldDB; A0A2Y9F3V6; -.
DR GeneID; 102980941; -.
DR CTD; 84889; -.
DR OrthoDB; 1421713at2759; -.
DR Proteomes; UP000248484; Chromosome 21.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR PANTHER; PTHR43243:SF20; CATIONIC AMINO ACID TRANSPORTER 3; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 3.
PE 4: Predicted;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022970}.
FT TRANSMEM 89..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 489..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..512
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
SQ SEQUENCE 542 AA; 59029 MW; F1FCB7F9BF6690EE CRC64;
MLWQELCRFG QKLVRRRTLE PGMAETRLAR CLTTLDLVAL GVGSTLGAAS VARAWSSAFD
NLIGNHISQT LQGSISLHVP HVLAEYPDFF AMGLVLLLTG LLALGASESA LVTKVFTVVN
LLVLGFVIIS GFIKGDLHNW KLTEEDYKLA MAGLNDTYSL GPLGSGGFVP FGFEGILRGA
ATCFYAFVGF DCIATTGEEA QNPQRSIPTG IVISLFVCFL AYFGVSSALT LMMPYYQLQP
ESPLPEAFLY SGWAPARYVV AIGSLCALST SLLGSMFPMP RVIYAMAEDG LLFRVLARIY
TGTHTPIVAT VVSGIIAAFM AFLFELTDLV DLMSIGTLLA YSLVAICVLI LRYQPDQEMR
NEEGEVELQE EKIHEAEKLT LQGLCCPLNS IPTPLSGQVV YVCSSLLALL LSVLCLVLAQ
WSTPLLSGDP VWTAVFVLLL MLITGITGVI WRQPQSSTPL HFKVPALPLL PLMSIFVNIY
LMMQMTAGTW ARFGVWMLIG FAIYFGYGMQ HSLEEVKSDQ PPLKSRAKTV DLDLSSACTH
SI
//
