ID A0A2Y9F4T2_PHYMC Unreviewed; 439 AA.
AC A0A2Y9F4T2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Transforming growth factor beta-1-induced transcript 1 protein {ECO:0000256|ARBA:ARBA00044082};
DE AltName: Full=Hydrogen peroxide-inducible clone 5 protein {ECO:0000256|ARBA:ARBA00044270};
GN Name=TGFB1I1 {ECO:0000313|RefSeq:XP_007115208.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007115208.1};
RN [1] {ECO:0000313|RefSeq:XP_007115208.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007115208.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus matrix
CC {ECO:0000256|ARBA:ARBA00004109}.
CC -!- SIMILARITY: Belongs to the paxillin family.
CC {ECO:0000256|ARBA:ARBA00005813, ECO:0000256|PIRNR:PIRNR037881}.
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DR RefSeq; XP_007115208.1; XM_007115146.4.
DR AlphaFoldDB; A0A2Y9F4T2; -.
DR GeneID; 102983657; -.
DR CTD; 7041; -.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09336; LIM1_Paxillin_like; 1.
DR CDD; cd09337; LIM2_Paxillin_like; 1.
DR CDD; cd09412; LIM4_Leupaxin; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR InterPro; IPR047075; Paxillin_TGFB1I1_LIM_dom1.
DR InterPro; IPR017305; Tgfb1i1/Leupaxin/TGFB1I1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR PANTHER; PTHR24214:SF38; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF00412; LIM; 4.
DR Pfam; PF03535; Paxillin; 1.
DR PIRSF; PIRSF037881; Leupaxin; 1.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PIRNR:PIRNR037881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 204..263
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 264..321
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 322..381
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 382..439
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 47502 MW; 8080CA3F1E74B2E8 CRC64;
MPRSGALKER PPEPLTSPLT QMGSGESSGA SGDKDHLYST VCKPRSPKPA APAAPPFSSS
CGVLGTGLCE LDRLLQELNA TQFNITDEIM SQFPSSKETA GEQKEDQSED KKRPSPPPSP
RPVLPKPSAT SATLELDRLM ASLSDFRVQN HLPASGPTQP PVPSSVNEGS PSPPGPAGKG
SLDTMLGLLQ SDLSRRGVPT QAKGLCGSCN KPIAGQVVTA LGRAWHPEHF VCGGCSTALG
GSSFFEKDGA PFCPECYFER FSPRCGLCNQ PIRHKMVTAL GTHWHPEHFC CVSCGEPFGD
EGFHEREGRP YCRRDFLQLF APRCQGCQGP ILDNYISALS ALWHPDCFVC RECFAPFSGG
SFFEHEGRPL CENHFHARRG SLCATCGLPV TGRCVSALGR RFHPDHFTCT FCLRPLTKGS
FQERAGKPYC QPCFLKLFG
//