ID A0A2Y9F620_PHYMC Unreviewed; 138 AA.
AC A0A2Y9F620;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Protein shisa-5 {ECO:0000256|ARBA:ARBA00040441};
DE AltName: Full=Scotin {ECO:0000256|ARBA:ARBA00041983};
GN Name=SHISA5 {ECO:0000313|RefSeq:XP_007115439.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007115439.1};
RN [1] {ECO:0000313|RefSeq:XP_007115439.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007115439.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC a role in p53/TP53-dependent apoptosis.
CC {ECO:0000256|ARBA:ARBA00037507}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the shisa family.
CC {ECO:0000256|ARBA:ARBA00038108}.
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DR RefSeq; XP_007115439.1; XM_007115377.4.
DR AlphaFoldDB; A0A2Y9F620; -.
DR GeneID; 102980764; -.
DR KEGG; pcad:102980764; -.
DR CTD; 51246; -.
DR OrthoDB; 5266769at2759; -.
DR Proteomes; UP000248484; Chromosome 18.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31395:SF14; PROTEIN SHISA-5; 1.
DR PANTHER; PTHR31395; SHISA; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 138 AA; 14664 MW; 89238427154E64B0 CRC64;
MSGFGTTVAV GLTIFVLSVV TIIICFTCSC CYLYKMCCRP RPVVTTTTST TVVHSPYSQA
PSVPPSYPGP TYQGYHAMPP QPGMPAAPYP TQYPPPYPAQ PMGPPAYHET MAGGAAMPYP
ASQPPYNPAY MDPPKAAP
//
