ID A0A2Y9F759_PHYMC Unreviewed; 2282 AA.
AC A0A2Y9F759;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Collagen alpha-6(VI) chain {ECO:0000313|RefSeq:XP_007115525.2};
GN Name=COL6A6 {ECO:0000313|RefSeq:XP_007115525.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007115525.2};
RN [1] {ECO:0000313|RefSeq:XP_007115525.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007115525.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR RefSeq; XP_007115525.2; XM_007115463.3.
DR STRING; 9755.ENSPCTP00005001461; -.
DR KEGG; pcad:102984497; -.
DR InParanoid; A0A2Y9F759; -.
DR OrthoDB; 5359724at2759; -.
DR Proteomes; UP000248484; Chromosome 1.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR CDD; cd01472; vWA_collagen; 2.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 8.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF00092; VWA; 8.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS50234; VWFA; 9.
PE 3: Inferred from homology;
KW Collagen {ECO:0000313|RefSeq:XP_007115525.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2282
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015878993"
FT DOMAIN 28..200
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 227..405
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 434..604
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 620..789
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 807..980
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 998..1169
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1185..1377
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1755..1900
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1963..2168
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1423..1719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2282 AA; 249295 MW; 29CDFBF7AEE5FCDD CRC64;
MKMLLTLLLM IICSHVSVNQ HSGPEYADVV FLVDSSDHLG TKSFPFVKTF INKMITSLPI
EAHKYRVGLA QYSDGLHREF QLSTFESRGP MLKHLKKNFR FLGGSLRIGN TLQEVHKTYF
SNGRDRRHFP LILVVLASAE SEDAVEEASE ALRNDGVRII SVGMQGVSEE TLKAMATDQF
HYSLRTVRDL STFSQNMTKI LKDAAQYKEG AVNDILVEVC QGPSVADVVF LLDMSINGSW
EDFDYLKEFL EESVSALDIK ENCMRVGLVA YSNETKVINP LSSGINKSEI LQDIQSLSPQ
AGKAYTGAAL RKIRKEVFSV QHGSRKNQGV PQIAVLVTHS PSEDNVTKAA VNLRRQGVTI
FTMGIEGASD AQLEKIASHP AEQYVSKLKT FSDLAAHNQT FLKKLRNQIT HTVSVISERT
ETLKSGCVDT EEADIYLLID GSGSTQATDF QEMKTFLSEV VEMFNIAPQK VRVGAVQYAD
RWDLEFEINK YTNKHDVGKA IENIRQLGGN TNTGAALNFT LGLLQKAKRQ RENRVPCHLV
VLTNGVSQDS ILGPANRLRE ELIHVYAIGV KEANETQLRE IAGEEKRVYY VHDFDALKDI
RNQVVQEICA EEACKEMKAD IMFLVDSSGS IGRENFIKMK TFMKNLVRKS QIGGDRVQIG
VVQFSDINKE EFQLNRYMSQ GEISDAIDRM AHIGETTLTG SALTFVSQYF SPAKGARPNI
RKFLILITDG EAQDTVKDPA VALRQEGIII YSVGVFGSNV TQLEEISGRP EMVFYVENFD
ILQHIEDDLV FGICSPREEC KRIEVLDVVF VIDSSGSIDH DEYNIMKDFM IDLVKKANVG
KNHVRFGALK YADDPEVLFY LDNLGTKRQV ISVLQNDQPM GGNTYTAKAL GFSDHMFTEA
RGSRLHKGVP QVLIVITDGE SHDADTLNAT AKALRDKGIL VLAVGIAGAN AVELLAMAGS
SDKYFFVETF GGLKGIFSDV SASVCNSSKV DCEIEKVDLV FLMDGSDSIH PDDFKKMKRF
LASVVQDFDV SVNRVHIGAA QFSHTYRPEF ALGTFIGKKE ISFQIENIQQ IFGYTHIGSA
LRQVGHYFQP DMGSRINTGT PQVLLVLTDG QSQDEVAQAA EELRHKGINI YSVGIGDVDD
QQLVQITGTA DKKLTVHNFD ELKKVKKRIV RNICTSGSES NCFVDIVVGF DISTQQNGQT
LLEGQSWMES YLQDILRAIR SLSGVSCEVG TETQVSVAFQ VTNAMEKYSP KFEIYSENIL
NSLKDVTVKR PSLLNANLLS SLWGAFQNKS AARGKVVLLF SDGLDDDVEK LEQKSDELRK
EGLNALITVA LDGATNSNEL ADLLYIEFGK GFEYRTQLTL GMRDLGSRLS KHLVSVAERT
CCCLFCKCIG GDGTVGDPGP AGKKGPPGFK GSEGYLGEEG IAGERGTTGP MGEQGTKGCY
GDKGPKGNRG LNGQEGEVGE SGIDGLNGEQ GDHGLPGAKG EKGDEGAQGI PGERGIPGDH
GAKGLCGDPG VPGFDNSIEG PKGLKGEYGR QGRRGWPGPP GTPGSRRKTA VHGQRGHTGP
QGKTGIPGPD GLAGSLGLKG PQGPRGEAGM KGEKGGLGSK GPQGLPGPAG EAGSQGRLGS
QGNKGEPGDV GEKGAIGLRG PRGLPGDDGN LGYGNVGSKG AKGQEGFPGE IGPKGEVGDP
GGPGETGPKG TRGKTVSAGL PGEPGSPGEL GPPGRKGVKG AKGLPSFSTC ELIQHVQDHS
PGRHGALRCP VHPTELVFAL DQSRGVTEPE FARMKEMMTS LLGGLRVREN HCSAGARVAV
LTYNSHARLL IRFSDAYRKD RLLRQIEALP YERSTSSRDI GKAMRFVSRN VFKRMLPGAH
TRRIATFFSG GPSADAQTIT TAGLEFSTLD IIPVVIAFSQ VPAIKHSFVI DDTGRFQVIM
VPHRIDSAPA LEGLQRCTFC YDICKPDASC DQARPLAMQS YMDTAFLLDG SRHVGSAEFE
DIRGFLGALL DHFEITPEPE TSVTGDRVAL LSHAPPHFLP NTQRSPVRSE FNLTTYKSKR
LMKRHVEESV QQLNGDAFIG HALQWTLNNV FLSTPNLRRN KVIFVISAGE TSHMDRETLK
KESLRAKCQG YALFVFSLGP SWNDQELEDL ASYPLDHHLV QLGRIHKPDH RYGVKFAKAF
ISSVRRAINK YPPINIKAKC YRLSSADTQQ PPRQLRSFLP GPHKATLKED VLQKAKFFQH
KKYLSRIARG SRDDTVQNFT RNTSHTFKSG KGVIKTAPKQ HDKEVLEEVS LRKHGKTLGL
NN
//
