ID A0A2Y9F818_PHYMC Unreviewed; 762 AA.
AC A0A2Y9F818;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Forkhead box protein M1 isoform X1 {ECO:0000313|RefSeq:XP_007117111.2, ECO:0000313|RefSeq:XP_007117112.2};
GN Name=FOXM1 {ECO:0000313|RefSeq:XP_007117111.2,
GN ECO:0000313|RefSeq:XP_007117112.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007117112.2};
RN [1] {ECO:0000313|RefSeq:XP_007117111.2, ECO:0000313|RefSeq:XP_007117112.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007117111.2,
RC ECO:0000313|RefSeq:XP_007117112.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_007117111.2; XM_007117049.4.
DR RefSeq; XP_007117112.2; XM_007117050.4.
DR STRING; 9755.ENSPCTP00005027908; -.
DR Ensembl; ENSPCTT00005030722; ENSPCTP00005027908; ENSPCTG00005019992.
DR KEGG; pcad:102984502; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000248484; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0032873; P:negative regulation of stress-activated MAPK cascade; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:Ensembl.
DR CDD; cd20029; FH_FOXM; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047516; FH_FOXM1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR042839; FOXM1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46878; FORKHEAD BOX PROTEIN M1; 1.
DR PANTHER; PTHR46878:SF1; FORKHEAD BOX PROTEIN M1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 239..332
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 239..332
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 82721 MW; 423AC51A7A0E2EE4 CRC64;
MKTSPRRPLI LKRRRLPLPV QNAPGDTSEE EPKGPPAQQE PAQPQASEEV AESNPCKFPA
GIKIMNHPTM PNTQVVAVPK NANIQSIITA LTAKGKESGS SGPNKFILIS CGGAPTRPAG
PQPQAQTSND PKRTEVITET LGPKSASKDV NLPRPPGALP GQRWENCAGG EAAGCTLDNS
LTNIQWLGKM TSDGLGSCSI KQEVEEKENR HLEQSQAKDA QAEGPLGASA SWPDSVSERP
PYSYMAMIQF AINSTERKRM TLKDIYAWIE DHFPYFKHIA KPGWKNSIRH NLSLHDMFVR
ETSANGKVSF WTIHPSANRY LTLDQVFKPL DPGSPQSPEH LESQQKRPNP ELRQNVAIKT
ELPLGARRKM KPLLPRVSSY LVPIQFPVNQ SLVLQPSVKV PLPLAASLMS SELARHSKRV
RIAPKVLLAD EGVAPLPTAG PVKEEKLLLG EGLAPLLPVQ SIKEEEVQPG EEAPRLGRPI
KVESPPLEEW PSPCPSVREE SSPSWEDSSR CPVPRPKKSY SGPKSPARCV SDLLVIKRRE
RREMSRSRRK QHLLPPCLDE PELCFSEGPG ASGRATAGAS QPASQQRGSS HEEGGPFKTP
IKEMLPVSST PSKSALPVTP ESWRLTPPAK VGGLDFSPVR TPQGAFGPLP DSLELADLSG
TPLKSVPLFD CPRELLDSEP FDITADPFGG CPPSDAEAPR PGSSEPQGAG LAANRSLTEG
LVLDTMNDSL SKILLDISFP GLEEDLLGSD DVSWAQFIPE LR
//