ID A0A2Y9F8X3_PHYMC Unreviewed; 1710 AA.
AC A0A2Y9F8X3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Sialoadhesin {ECO:0000313|RefSeq:XP_007117475.2};
GN Name=SIGLEC1 {ECO:0000313|RefSeq:XP_007117475.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007117475.2};
RN [1] {ECO:0000313|RefSeq:XP_007117475.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007117475.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007117475.2; XM_007117413.4.
DR STRING; 9755.ENSPCTP00005010813; -.
DR Ensembl; ENSPCTT00005011966; ENSPCTP00005010813; ENSPCTG00005007659.
DR KEGG; pcad:102983375; -.
DR InParanoid; A0A2Y9F8X3; -.
DR OrthoDB; 5360480at2759; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR47243; SIALOADHESIN; 1.
DR PANTHER; PTHR47243:SF1; SIALOADHESIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 6.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 16.
DR SMART; SM00408; IGc2; 15.
DR SUPFAM; SSF48726; Immunoglobulin; 13.
DR PROSITE; PS50835; IG_LIKE; 13.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1710
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016052186"
FT TRANSMEM 1643..1666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..231
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..320
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 326..405
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 415..509
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 511..593
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 708..790
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 798..887
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 897..976
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 983..1082
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1084..1165
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1259..1341
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1444..1523
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1537..1630
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 1710 AA; 182484 MW; 420B057FCB42EE51 CRC64;
MDFPLQLLLL ASSIPAGLTS WGVSSPQAVQ GVRGSCLVIP CIFSFPASVE VPHGITTIWY
YDYSGNRQVV SHSGNPQLVE ARFQGRALLV GRAEHKLCSL LLRDLRAEDS GSYNFRFEIS
EGNRWSDVTG TVVTVTEEPS VPTIASPAEL REGMVVDFNC STPYACLQEP VNLQWQGQDP
TRSITSNLQK LEPTGISHLE TLHMALSWQD HGRTLRCQLS VANHRTQGEI HLQVQYAPKG
VKILLSPSGR NILPGDLVTL TCQVNNSYPQ VSSVQWVKDG THLKDQSRVL QLPQAAWEDA
GIYTCEAGNG VGSSVSPPVS LHVFMAEVQV SPAGSILENQ TVTLACNTPK EAPSELRYRW
YKNHALMEDT HSRILQLHSA TRADTGFYFC EVQNAQGSER SGLVSVVVSH PPLAPDLTAF
LETQAGLVGI LQCSVVSEPM ATLVLSHGGL ILASTSGEGD YSPRFSVSSA PNSLRLEIRD
LGPTDSGEYT CSATNSLGNA SSALDFHVNA ARLLISPAAE VAEGQAVTLS CRSNLSPTPD
VRFSWYRNGA LLLKGPSSSL LLPAASSTDA GSYHCWAQDG HSTSGPSSPA VLTVLYAPRQ
PMFTARLDPD TAGAGAGRRG ILLCRVDSDP PAQLRLLHRN CVVASSLPSG GSCSTCGGCS
QRTKVTRAPN LLRVEIQDPV LEDEGMYLCE ASSLLGNASA SATFNAQATV LVITPSHTLQ
EGTGANLTCT VGREAGGPAN FSWFRDGALW AQGPLETLTL LPVTRRDAAL YACRILTEAG
AQLSTPVVLS VLYPPDPPKL SALLDVDQGH TALFICTVDS RPLAQLSLFH GEHLLATSPG
PRLSSRGRLQ AKATANSLQL EVQDLSLADS GSYRCEATNV LGSANTSLFF QVRGAWVRVS
PSPELREGQA VVLSCQVPTG VLEGTSYRWY RDGQPLQEST SATVHFAAIT LSQAGAYHCQ
AQAPGSATTN LAVPVSLHVS YAPREATLTP LMDTGPGRLG LLLCRVNSDP PAQLRLLHGD
LLVASTLQGV GELAGSSPRL QVAVAPNMLR LEIHNAVLED EGVYTCEATN ALGQASASAT
FDAQAVSVQA WPKATVQEGQ LVNLTCLVWA THVAQLTYTW YQDGQQRPGA VHSITLPNVT
VMDAASYRCG VLTPGQALHL SRPVTLDVLY APRRMRLTYL LESRGGQLAL VLCTVDSRPP
AQLALSHAGR LLVSSTTASV PNTLRLELWE PGPSDEGLYS CSARSPLGQA NMSLELRLEG
VRVTLAPSAT VPEGAPVTVT CEDPAARPPT HYAWYHNSRW LQDGSAASLS FPVATRAHAG
TYTCQVQDAQ GTRSSRPTAL HVLYAPRDAV LSSFWDSRAS PMAVVQCTVD SEPPAELALS
RDGKVLATSQ GVHGLAVGTG HIQVARNALR LRVQDVPSGD KDTYVCTARN LLGSVSTTGQ
LQAEGVHVVA EPGLDVPEGT ALNLSCRLPG GAGPMGNSTF AWFWNGRQLH TEPVPTLAFT
HVALAQAGMY HCRAELPTGA TTSAPVMLRV LYPPKTPTMT VFVEPEGGVQ GILDCRVDSE
PLASLTIHLG SRLVASSQPQ IAPAKPHIHV SVTPNALRVD IEELRPGDQG EYVCSASNAL
GSASAATYFG TRALHRLHLF QQLLWVLGLL AGLLFLLLGL GACYAWRRRH FHKLRVCENS
VEMASQKETT QLIDPDAATF VTLSCALPLS
//
