ID A0A2Y9FBM1_PHYMC Unreviewed; 607 AA.
AC A0A2Y9FBM1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Suppressor of cytokine signaling 7 isoform X2 {ECO:0000313|RefSeq:XP_007118011.2};
GN Name=SOCS7 {ECO:0000313|RefSeq:XP_007118011.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007118011.2};
RN [1] {ECO:0000313|RefSeq:XP_007118011.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007118011.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_007118011.2; XM_007117949.4.
DR AlphaFoldDB; A0A2Y9FBM1; -.
DR KEGG; pcad:102988281; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10388; SH2_SOCS7; 1.
DR CDD; cd03741; SOCS_SOCS7; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035866; SOCS7_SH2.
DR InterPro; IPR037346; SOCS7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF37; SUPPRESSOR OF CYTOKINE SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 425..534
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 529..579
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 28..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..56
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..260
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 65446 MW; 3F6AD0332BF01AB1 CRC64;
MQGAELRDGE AAAAAASYRV LSRLLGYGEA APEPGPPPPP PGHGPAPPPF LARPGPRGSR
PPQLMVFRNV GRPPEEEDAE AAREPGPSEL LCPRHRCALD PKALPPGLAL ERTWGPAAGL
EAQLAALGLG QPAGPGVKTV GGGCCPCPCP PQPPPPQPQP PAAAPQAGED PTETSDALLV
LEGLESEAES LETNSCSEEE LSSPGRGGGG GGRLLLQPPG PELPPVPFPV QDLVPPGRLS
RGEQQQPPPP PPPPGPLRPL AGPSRKSSLK IRLSRLFRTK SCNGGSGGGD GAGKRPSGEL
AASAASLTDV GGFAGRELDA GRKPRLTRTQ SAFSPVSFSP LFTGETVSLV DVDISQRGLT
SPHPPTPPPP PRRSLSLLDA FPRIAPLRAA ESLHSQPPPP LQCPLYRPDS SSFAASLREL
EKCGWYWGPM NWEDAEMKLK GKPDGSFLVR DSSDPRYILS LSFRSQGITH HTRMEHYRGT
FSLWCHPKFE DRCQSVVEFI KRAIMHSKNG KFLYFLRSRV PGLPPTPVQL LYPVSRFSNV
KSLQHLCRFR IRQLVRIDHI PDLPLPKPLI SYIRKFYYYD PQEEVYLSLK EAQLISKQKQ
EVLEPST
//
