ID A0A2Y9FCR6_PHYMC Unreviewed; 935 AA.
AC A0A2Y9FCR6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=DENN domain-containing protein 2C isoform X1 {ECO:0000313|RefSeq:XP_007119669.1};
GN Name=DENND2C {ECO:0000313|RefSeq:XP_007119669.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007119669.1};
RN [1] {ECO:0000313|RefSeq:XP_007119669.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007119669.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007119669.1; XM_007119607.4.
DR AlphaFoldDB; A0A2Y9FCR6; -.
DR STRING; 9755.ENSPCTP00005001536; -.
DR Ensembl; ENSPCTT00005001689; ENSPCTP00005001536; ENSPCTG00005001128.
DR GeneID; 102994473; -.
DR KEGG; pcad:102994473; -.
DR CTD; 163259; -.
DR InParanoid; A0A2Y9FCR6; -.
DR OrthoDB; 5398783at2759; -.
DR Proteomes; UP000248484; Chromosome 4.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15288:SF6; DENN DOMAIN-CONTAINING PROTEIN 2C; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 498..895
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 73..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 935 AA; 107605 MW; BA1A6B813895B30B CRC64;
MHPTGNMDVG FSRSAVHTLS RSHCKNIKQK ISQWEGRTNG KSNPDKCDPK DFGVSYNNCN
QEILLKRNPV AEGKSKKLDV TNSQNVDQGI NEDAKSHSQS EDESEKREYD DTHFFKNESG
SNWVCSRAKQ IESWKEVLDP ETSLPPGNFY TSQILWKKIE ALPPDKVLNL ALEHCDSSEK
ELHFRGLGSS YGVTKSLENI YSEPEGQECG PSVNPLPKPR RTFRYLSESG VMPYKERNCD
RKYCENNSCT ESSLASSQEP EPKKYDRKIR GRSKRKSFEF EDIQHFRNQN SQKIHEELRR
NSGSALYYTQ SEDNIYEDII YPTKENPYED IPVHPLRMWR SPSTWKLPPP KSAFKAPKLP
SKPQFLHRKT MELKNSQVYL RSKLTKDTTL PVTLTEWKLF RAGEVANRKR KNLPRLVLKI
DDIFESKRGK KRVKLHPYTG KDVPPSKGET SGYESDAEYL PKSRYKRIAQ LQQSSKRNPH
YQTLERDLIE LQEQQLFELF VVVSLQKKPS EISYIPQVIQ QFPSKGDHGF KQSRDTEERL
KVIPKFCFPD SKDWVPTSEL KSETFSFVLT GEDGSRWFGY CKKLLPEGKG KRLPEVYCMV
SRLGCFNLFS KILDEVEKRR EMSPALVYPF MRSVMEAPFP APGRTITVKS YLPGAGDGSI
ELCRPLDSRL EHVDFECLFK CLSVCHLIRV CASLLLERRI IFVANSLSTL SKCGHAVVAT
LYPFTWQHTY IPVLPASMID IVCSPTPFLI GILSCSLPQL QDLPIEEVLI VDLCADKFLQ
EVSDEDEILP PKLQAALIQI LEERNEILAQ EQNFLQEDVT LNSLVSEAFV RFFVELVGHY
SLSMTVTERG ERVFQREPFR KSHTSRSVRH FLDLFMETQM FAGFIQDREL RKSGVKGLFE
VRALQYLETI PESEPSGVNR ILRSLGSKMK FLQKK
//
