ID A0A2Y9FDI7_PHYMC Unreviewed; 266 AA.
AC A0A2Y9FDI7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Gap junction beta-4 protein {ECO:0000313|RefSeq:XP_007120245.3};
GN Name=GJB4 {ECO:0000313|RefSeq:XP_007120245.3};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007120245.3};
RN [1] {ECO:0000313|RefSeq:XP_007120245.3}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007120245.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_007120245.3; XM_007120183.3.
DR AlphaFoldDB; A0A2Y9FDI7; -.
DR STRING; 9755.ENSPCTP00005006156; -.
DR KEGG; pcad:102991883; -.
DR InParanoid; A0A2Y9FDI7; -.
DR OrthoDB; 5301774at2759; -.
DR Proteomes; UP000248484; Chromosome 3.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0005243; F:gap junction channel activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002270; Connexin-30.3.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF30; GAP JUNCTION BETA-4 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01142; CONNEXINB5.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..40
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 41..266
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040759795"
FT DOMAIN 42..75
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 141..208
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
SQ SEQUENCE 266 AA; 30079 MW; 1C58B57612CC89B8 CRC64;
MNWAFLRGIL NGANKHSRAL GRIWLSVVFV FRVPVHVVAA EEVQGDEPKD FLCDTRQPGC
PNVCYNESFP VSHVRLRALQ LILVTCPSRL VVMRVAYRQE RKRKHRLRHG PDVPSLYDNL
DKKRGGLWWT ELLSVLLKAA VDSGFLYIFH RLYQDYDMPH VAARSESPCP RTVDCYISRP
TGKKVFTYLM VAAALLCTLL NLSEVTYLVG KRCLETLGSR RRGSRRWTHL PETCPPCALS
QGEHPQDGNS VLMKVGSTTV DAGGYP
//
