ID A0A2Y9FFC1_PHYMC Unreviewed; 226 AA.
AC A0A2Y9FFC1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=E3 ubiquitin-protein ligase RNF186 {ECO:0000313|RefSeq:XP_007121638.1};
GN Name=RNF186 {ECO:0000313|RefSeq:XP_007121638.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007121638.1};
RN [1] {ECO:0000313|RefSeq:XP_007121638.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007121638.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007121638.1; XM_007121576.1.
DR AlphaFoldDB; A0A2Y9FFC1; -.
DR STRING; 9755.ENSPCTP00005021454; -.
DR Ensembl; ENSPCTT00005023639; ENSPCTP00005021454; ENSPCTG00005015334.
DR GeneID; 102976763; -.
DR KEGG; pcad:102976763; -.
DR CTD; 54546; -.
DR InParanoid; A0A2Y9FFC1; -.
DR OrthoDB; 3043515at2759; -.
DR Proteomes; UP000248484; Chromosome 3.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0035519; P:protein K29-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
DR GO; GO:2000785; P:regulation of autophagosome assembly; IEA:Ensembl.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22791:SF28; E3 UBIQUITIN-PROTEIN LIGASE RNF186; 1.
DR PANTHER; PTHR22791; UNCHARACTERIZED; 1.
DR Pfam; PF14634; zf-RING_5; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 154..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..84
FT /note="RING-type"
FT /evidence="ECO:0000259|SMART:SM00184"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 24135 MW; 96A04CF7461B3267 CRC64;
MACSELLQQP QLTSKETTAS NTAGPAGGHR GSTDGDLECL VCREPYSSAR RPKLLGCQHT
FCAVCLKLLL CVQDDTWSIA CPLCRKVTAV PGGLICSLRD QEAMLGRLAR PGPEVRLCPQ
GLVNPATLIA GHPSLAGEDE QDTESANCLA ARRLAAHLLL LALLVALTLP FIYPGVVCWM
LSFIIVLALL LSMLLCCGRS SQGSRCSSPR TLFCREQKPS EISSVA
//
