ID A0A2Y9FFH6_PHYMC Unreviewed; 1525 AA.
AC A0A2Y9FFH6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Rho guanine nucleotide exchange factor 12 isoform X2 {ECO:0000313|RefSeq:XP_007121769.1};
GN Name=ARHGEF12 {ECO:0000313|RefSeq:XP_007121769.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007121769.1};
RN [1] {ECO:0000313|RefSeq:XP_007121769.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007121769.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_007121769.1; XM_007121707.4.
DR Ensembl; ENSPCTT00005032645; ENSPCTP00005029692; ENSPCTG00005021172.
DR GeneID; 102996900; -.
DR CTD; 23365; -.
DR OrthoDB; 2875542at2759; -.
DR Proteomes; UP000248484; Chromosome 16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13390; PH_LARG; 1.
DR CDD; cd08754; RGS_LARG; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR037801; ARHGEF12_PH.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR037884; LARG_RGS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 53..117
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 768..958
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1000..1113
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 18..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1367..1386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1525 AA; 170968 MW; CA2C003DADDED576 CRC64;
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERST SHDFDPTGLV HRCVIIQKDD
NGFGLTVSGD NPVFVQSVKE DGAAMRAGVQ TGDRIIKVNG TLVTHSNHLE VVKLIRSGSY
VALTVQGRPP GSPQFPLADS EVEPSVVGHM SPIMTSPHSP GASGNMERIT SPVLMGEENN
VVHNQKVEIL RKMLQKEQER LQLLQEDYSR TPAQRLLKEI QEAKKHIPQL QEQLSKATGS
AQDGAAVTSS KPLGDGLAVS EIEADPGDGL GRIDYGSGDA SRPGSDSADS PKSGLKERIY
LEENPDKSEV IQDADTQSLI GSPSTRIAPH IIGAEDDDFG TEHEQINGQC SCFQSIELLK
SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKQTNSKETR RVFLEFHQFF LDRSAHLKVS
VPDEISVDLE KRRPELIPED LHRHYIQTMQ ERVHPEVQRH LEDFRQKRSM GLTLAESELT
KIDAERDKDR VTLEKERACA EQIVAKIEEV LMTAQAVEED KSSTMQYVIL MYMKHLGVKV
KEPRNLEHKR GRIGFLPKIK QSMKKDREGE EKGKRRGFPS ILGPPRRPSR HDNSAIGRAM
ELQKQRHPKH ISTPSSVSPE PQDSAKLRQS GLASEGADIG YLPANSMSSM VSGATLSQEG
GKENDMGSKQ VGETPASGDS LDGTPRTPST IFDFPPPPLD QVQEEEWEVE RVTEHGTPKP
FRKFDSIAFG ESQSEDEQFE NDLETDPPNW QQLVSREVLL ALKPCEIKRQ EVINELFYTE
RAHVRTLKVL DQVFYQRVSR EGILSPSELR KIFSNLEDIL QLHIGLNEQM KAVRKRNETS
VIDQIGEDLL TWFSGPGEEK LKHAAATFCS NQPFALEMIK SRQKKDSRFQ TFVQDAESNP
LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPTEREK VKKAADHCRQ ILNYVNQAVK
EAENKQRLED YQRRLDTSNL KLSEYPNVEE LRNLDLTKRK MIHEGPLVWK VNRDKTIDLY
TLLLEDILVL LQKQDDRLVL RCHSKILAST GDSKHTFSPV IKLNTVLVRQ VATDNKALFV
ISMSDNGAQI YELVAQTVSE KTVWQDLICR MAASVKEQST KPIPLPQSPP CEGDNDEEEP
PKLKVEHHGI SVTGLQSPDR DLGLESPLMS SKPQSHSLDT SGKSEVDDLF VAERQFAKEQ
HADGTLKEVG VNYQITIPDP HLPVSEERWA LDALRNLGLL KQLLVQQLGL TEKSTQEDWP
HFPRCRTASL GLQADSGTQN PENIKAYHPC EGQMPFRTGT GDISTCYSPR TSTESSAPRD
SVVLAFQDSQ ASNILVMDHM IMTPEMPPAE PEGGLDESGE HFFDAREAHS DDNPSEGDGA
VKKEEKDVNL RISGTCLILD GYETVQESST DEEVASSLPP QPATGIPSMD STPRQQRSPQ
NAHFDGAVSP FTPEFLVQQR WGAMEDSCFE IRSPSSCADS QSQIMEYIRK IEADLEHLKK
VEESYTILCQ RLAGSALTDK HSDKS
//
