ID A0A2Y9FGZ9_PHYMC Unreviewed; 1268 AA.
AC A0A2Y9FGZ9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=3'-5' RNA helicase YTHDC2 isoform X2 {ECO:0000313|RefSeq:XP_007122655.1, ECO:0000313|RefSeq:XP_054942687.1};
GN Name=YTHDC2 {ECO:0000313|RefSeq:XP_007122655.1,
GN ECO:0000313|RefSeq:XP_054942687.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007122655.1};
RN [1] {ECO:0000313|RefSeq:XP_007122655.1, ECO:0000313|RefSeq:XP_054942687.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007122655.1,
RC ECO:0000313|RefSeq:XP_054942687.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007122655.1; XM_007122593.4.
DR RefSeq; XP_007122656.1; XM_007122594.1.
DR RefSeq; XP_054942687.1; XM_055086712.1.
DR AlphaFoldDB; A0A2Y9FGZ9; -.
DR GeneID; 102984066; -.
DR KEGG; pcad:102984066; -.
DR CTD; 64848; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000248484; Chromosome 8.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd17987; DEXHc_YTHDC2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_007122655.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_007122655.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 41..207
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 344..376
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 450..622
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1126..1256
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1002..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1090
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1268 AA; 142845 MW; F981003092E612AA CRC64;
MSKTSGRLNN GIPQIPVKRG ESEFDSFRQS LPVFEKQEEI VKIIKENKVV LIVGETGSGK
TTQIPQFLLD DCFQNGIPCR IFCTQPRRLA AIAVAERVAA ERRERIGQTI GYQIRLESRV
SPKTLLTFCT NGVLLRTLMG GDSSLSTVTH VIVDEVHERD RFSDFLLTKL RDLLQKHPTL
KLILSSAALD VNLFMRYFGS CPVTYIQGRP FEVKEMFLED ILRTTGYTNK EMLKYKKEKQ
REERQQTTLT EWYSAQENTF KPESQRQRAV PNVTEEYDLL DDGGDAVFSQ LTEKDVNCLE
PWLIKEMDAC LSDIWLHKDV DAFAQVFHLI LTENVSVDYT HSETSATALM VAAGRGFSSQ
VEQLISMGAN VHIKASNGWM ALDWAKHFGQ TEIVDLLESY SASLEFGNLD ESSLVQTNES
DLSAEDRELL KAYHHSFDDE KVDLDLIMHL LYNICHSCDS GAILIFLPGY DEIVGLRDRI
LFDDKRFAEN THRYQVFMLH SNMQTSDQKK VLKNPPAGVR KIILSTNIAE TSITVNDVVF
VIDSGKMKEK SFDALNFVTM LKMVWISKAS AIQRKGRAGR CRPGICFRLF SRLRFQNMLE
FQTPELLRMP LQELCLHTKL LAPVNCPIAD FLMKAPEPPP ALIVRNAVHM LKTIDAMDAW
EGLTELGYHL ADLPVEPHLG KMVLCAVVLK CLDPILTIAC TLAYRDPFVL PVQASQKRAA
MLCRKRFTAG TFSDHMALLR AFQAWQKARS DGWERAFCEK NFLSQATMEI IVGMRTQLLG
QLRASGFVRA RGGGDIRDVN TNSENWAVVK AALVAGMYPH LVHVDRENVV LTGPKEKKVR
FHPTSVLSQP QYKKIPPANG QAAAIQALPT DWLIYDEMTR AHRIANIRCC SAVTPVTVLI
FCGPARLASN ALQEPSSFRA DGIPNDSSDS EMEDRTTANL AALKLDEWLN FKLEPEAASL
LLQLRQKWHS LFLRRMRAPS KPWSQVDEAT IRAIIAVLST EEQSAGLQQP SGIGQRPRPM
SSEELPLASS WRSNNSRKIS ADTEFSDEST TAERVLMKSP SPALHPPQKY KDRGILRPKR
STDDKSDQSS VKSTDSNSYP SPCASPSPPS SGKGSKSPSP RPNMPIRYFI MKSSNLRNLE
ISQQKGIWST TPSNERKLNR AFWESSMVYL VFSVQGSGHF QGFSRMSSEI GREKSQDWGS
AGLGGVFKVE WIRKESLPFQ FAHHLLNPWN DNKKVQISRD GQELEPQVGE QLLQLWERLS
LGEKTTAD
//
