ID A0A2Y9FIF8_PHYMC Unreviewed; 222 AA.
AC A0A2Y9FIF8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Ras-related protein Rab-21 {ECO:0000256|ARBA:ARBA00014900};
GN Name=RAB21 {ECO:0000313|RefSeq:XP_007123949.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007123949.1};
RN [1] {ECO:0000313|RefSeq:XP_007123949.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007123949.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007123949.1; XM_007123887.4.
DR AlphaFoldDB; A0A2Y9FIF8; -.
DR STRING; 9755.ENSPCTP00005011304; -.
DR Ensembl; ENSPCTT00005012489; ENSPCTP00005011304; ENSPCTG00005008030.
DR GeneID; 102996717; -.
DR KEGG; pcad:102996717; -.
DR CTD; 23011; -.
DR InParanoid; A0A2Y9FIF8; -.
DR OrthoDB; 5483572at2759; -.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0098559; C:cytoplasmic side of early endosome membrane; IEA:Ensembl.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0019003; F:GDP binding; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:Ensembl.
DR GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR GO; GO:0008089; P:anterograde axonal transport; IEA:Ensembl.
DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:2000643; P:positive regulation of early endosome to late endosome transport; IEA:Ensembl.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR GO; GO:0017157; P:regulation of exocytosis; IEA:Ensembl.
DR CDD; cd04123; Rab21; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041833; Rab21.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47978; -; 1.
DR PANTHER; PTHR47978:SF70; RAS-RELATED PROTEIN RAB-21; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 222 AA; 24088 MW; CC852226B3FAF748 CRC64;
MAAAGGGGAA AGRAYSFKVV LLGEGCVGKT SLVLRYCENK FNDKHITTLQ ASFLTKKLNI
GGKRVNLAIW DTAGQERFHA LGPIYYRDSN GAILVYDITD EDSFQKVKNW VKELRKMLGN
EICLCIVGNK IDLEKERHVS IQEAESYAES VGAKHYHTSA KQNKGIEELF LDLCKRMIET
AQVDERAKGN GSSQPGAARR GVQIIDDEPQ AQSGGGGCCS SG
//
