ID A0A2Y9FII3_PHYMC Unreviewed; 1073 AA.
AC A0A2Y9FII3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Semaphorin-6D isoform X1 {ECO:0000313|RefSeq:XP_007122390.1};
GN Name=SEMA6D {ECO:0000313|RefSeq:XP_007122390.1,
GN ECO:0000313|RefSeq:XP_028351491.1, ECO:0000313|RefSeq:XP_028351492.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|RefSeq:XP_007122390.1};
RN [1] {ECO:0000313|RefSeq:XP_007122390.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007122390.1,
RC ECO:0000313|RefSeq:XP_028351491.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_007122390.1; XM_007122328.3.
DR RefSeq; XP_007122390.1; XM_007122328.4.
DR RefSeq; XP_028351491.1; XM_028495690.2.
DR RefSeq; XP_028351492.1; XM_028495691.2.
DR STRING; 9755.ENSPCTP00005023425; -.
DR Ensembl; ENSPCTT00005025802; ENSPCTP00005023425; ENSPCTG00005016729.
DR GeneID; 102974544; -.
DR KEGG; pcad:102974544; -.
DR CTD; 80031; -.
DR OrthoDB; 5399685at2759; -.
DR Proteomes; UP000248484; Chromosome 11.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0014909; P:smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR CDD; cd11269; Sema_6D; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF65; SEMAPHORIN-6D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1073
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041069100"
FT TRANSMEM 663..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..512
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 744..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1073 AA; 119760 MW; 8D9DAFAFF34EC344 CRC64;
MRFFLLCAYM LLLMISQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ
LMLKIRDTLY IAGRDQVYTV NLNEIPKTEI IPNKKLTWRS RQQDRENCAM KGKHKDECHN
FIKVFVPRND EMVFVCGTNA FNPMCRYYRL NTLEYDGEEI SGLARCPFDA RQTNVALFAD
GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI
AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSV
TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF RGRFKEQKTP DSVWTAVPED
KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRIRYR
LTAIAVDHSA GPHQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNLAKCNAE
NEEDRKVISL QLDKDHHALY VAFSSCVIRI PLSRCERYGS CKKSCIASRD PYCGWLSPGA
CGEVTPGMLA GGFEQDTEYG NTAHLGDCHE ILPTSTTPDY KIFGGPTSDM EVSSSSVTTM
ASIPEITPKV IDTWRPKLTS SRKFVVQDDP NTSDFTDPLS GIPKGVRWEV QSGESNQMVH
MNVLITCVFA AFVLGAFIAG VAVYCYRDMF VRKNRKIHKD AESAQSCTDS SGSFAKLNGL
FDSPVKEYQQ NIDSPKLYSN LLTSRKELPP SGDTKSMVMD HRGQPPELAA LPTPESTPVL
HQKTLQAMKS HSDKAHNHGA SRKETPQFFP SSPPPHSPLS HGHIPSAIVL PNATHDYNTS
FSNSNAHKAE KKLQNIDHPL TKSSSKRDHR RSVDSRNTLN DLLKHLNDPN SNPKAIMGDI
QMAHQTLMLD PVGPMSEVPP KVPNREASLY SPPSTLPRNS PTKRVDVPTT PGVPMTSLER
QRGYHKNSSQ RHSISAMPKN LSSPNGVLLS RQPSMNRGGY MPTPAGAKVD YIQGTPVSVH
LQPSLSRQSS YTSNGTLPRT GLKRTPSLKP DVPPKPSFVP QTTSVRPLNK YTY
//
