ID A0A2Y9FJV6_PHYMC Unreviewed; 657 AA.
AC A0A2Y9FJV6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Histidine ammonia-lyase {ECO:0000256|ARBA:ARBA00017271, ECO:0000256|RuleBase:RU004479};
DE EC=4.3.1.3 {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|RuleBase:RU004479};
GN Name=HAL {ECO:0000313|RefSeq:XP_007125193.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007125193.1};
RN [1] {ECO:0000313|RefSeq:XP_007125193.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007125193.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000171,
CC ECO:0000256|RuleBase:RU004479};
CC -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00005113, ECO:0000256|RuleBase:RU004479}.
CC -!- SIMILARITY: Belongs to the PAL/histidase family.
CC {ECO:0000256|ARBA:ARBA00007238, ECO:0000256|RuleBase:RU003954}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007125193.1; XM_007125131.1.
DR AlphaFoldDB; A0A2Y9FJV6; -.
DR STRING; 9755.ENSPCTP00005008664; -.
DR Ensembl; ENSPCTT00005009549; ENSPCTP00005008664; ENSPCTG00005005851.
DR GeneID; 102978170; -.
DR KEGG; pcad:102978170; -.
DR CTD; 3034; -.
DR InParanoid; A0A2Y9FJV6; -.
DR OrthoDB; 1030318at2759; -.
DR UniPathway; UPA00379; UER00549.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR005921; HutH.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR NCBIfam; TIGR01225; hutH; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 3: Inferred from homology;
KW Histidine metabolism {ECO:0000256|ARBA:ARBA00022808,
KW ECO:0000256|RuleBase:RU004479};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU003954};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
SQ SEQUENCE 657 AA; 72328 MW; 8447D2A4239BC379 CRC64;
MPRYTVHVRG EWLAVPCQDA QLTVGWLGRE AVRRYIKNKP DNGGFASVDN VSFLVRRCKG
LGLLDHEDPL EVALEDNEFV EVVIEGDAMS SDFIPSQPEG VYLYSKYREP EKYIALDGDS
LTTEDLVNLG KGHYKIKLTP TAEKKVQNSR EVIESIVKEK TVVYGITTGF GKFARTVIPV
SKLEELQVNL VRSHSSGVGK PLIPERCRML LALRINVLAK GYSGISLETL KQVIEVFNAS
CLPYVPEKGT VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLAAH GLKPIVLKPK
EGLALINGTQ MITSLGCEAV ERASAIARQA DIVASLTLEV LKGTTKAFDT DIHAVRPHRG
QVEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQIHGVVNDT IAFAKNIITT
EINSATDNPM VFARRGETVS GGNFHGEYPA KALDYLAIGV HELAAISERR IERLCNPSLS
ELPAFLVAEG GLNSGFMIAH CTAAALVSEN KALCHPSSVD SLSTSAATED HVSMGGWAAR
KALRVIEHVE QVLAIELLAA CQGIEFLRPL KTTTPLERVY DLVRSVVRPW IKDRFMAPDI
EAAHRLLIEQ KVWEVAAPYI EKYRMEHIPE SRPVSPTAFS LEFLHKKSTK ISESEDL
//
