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Database: UniProt
Entry: A0A2Y9FKB5_PHYMC
LinkDB: A0A2Y9FKB5_PHYMC
Original site: A0A2Y9FKB5_PHYMC 
ID   A0A2Y9FKB5_PHYMC        Unreviewed;       172 AA.
AC   A0A2Y9FKB5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 {ECO:0000256|ARBA:ARBA00016384, ECO:0000256|PIRNR:PIRNR017016};
GN   Name=NDUFA8 {ECO:0000313|RefSeq:XP_007123670.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007123670.1};
RN   [1] {ECO:0000313|RefSeq:XP_007123670.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007123670.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|PIRNR:PIRNR017016}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000256|ARBA:ARBA00011533}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|PIRNR:PIRNR017016}. Mitochondrion intermembrane space
CC       {ECO:0000256|ARBA:ARBA00004569}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA8 subunit family.
CC       {ECO:0000256|ARBA:ARBA00010705, ECO:0000256|PIRNR:PIRNR017016}.
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DR   RefSeq; XP_007123670.1; XM_007123608.2.
DR   AlphaFoldDB; A0A2Y9FKB5; -.
DR   STRING; 9755.ENSPCTP00005022021; -.
DR   Ensembl; ENSPCTT00005024259; ENSPCTP00005022021; ENSPCTG00005015736.
DR   GeneID; 102974829; -.
DR   KEGG; pcad:102974829; -.
DR   CTD; 4702; -.
DR   InParanoid; A0A2Y9FKB5; -.
DR   OrthoDB; 1327569at2759; -.
DR   Proteomes; UP000248484; Chromosome 9.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl.
DR   InterPro; IPR010625; CHCH.
DR   InterPro; IPR016680; NDUFA8.
DR   PANTHER; PTHR13344:SF0; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8; 1.
DR   PANTHER; PTHR13344; NADH-UBIQUINONE OXIDOREDUCTASE; 1.
DR   Pfam; PF06747; CHCH; 1.
DR   PIRSF; PIRSF017016; NDUA8; 1.
DR   PROSITE; PS51808; CHCH; 2.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW   ECO:0000256|PIRNR:PIRNR017016}; Membrane {ECO:0000256|PIRNR:PIRNR017016};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|PIRNR:PIRNR017016};
KW   Mitochondrion inner membrane {ECO:0000256|PIRNR:PIRNR017016};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Respiratory chain {ECO:0000256|PIRNR:PIRNR017016};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR017016}.
FT   DOMAIN          78..111
FT                   /note="CHCH"
FT                   /evidence="ECO:0000259|Pfam:PF06747"
FT   REGION          133..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  20047 MW;  A535479A0C0C87B6 CRC64;
     MPGIVELPTL EDLKVQEVKV SSSVLKAAAH HYGAQCDKPN KEFMLCRWEE KDPRRCLEES
     KLVNQCALDF FRQIKQHCSE PFTEYWTCID YSGLQLFRQC RKQQAKFDEC VLDKLGWVRP
     DLGELSKVTK VKTDRPLPEN PYDSRARPEP NPETEGDLKP AKHGSRLFFW TM
//
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