ID A0A2Y9FLC2_PHYMC Unreviewed; 331 AA.
AC A0A2Y9FLC2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Homeobox protein Hox-C13 isoform X1 {ECO:0000313|RefSeq:XP_007125866.2};
GN Name=HOXC13 {ECO:0000313|RefSeq:XP_007125866.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007125866.2};
RN [1] {ECO:0000313|RefSeq:XP_007125866.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007125866.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317}.
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DR RefSeq; XP_007125866.2; XM_007125804.3.
DR AlphaFoldDB; A0A2Y9FLC2; -.
DR STRING; 9755.ENSPCTP00005012067; -.
DR Ensembl; ENSPCTT00005013340; ENSPCTP00005012067; ENSPCTG00005008577.
DR KEGG; pcad:102984653; -.
DR InParanoid; A0A2Y9FLC2; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR GO; GO:0035878; P:nail development; IEA:Ensembl.
DR GO; GO:0043587; P:tongue morphogenesis; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR022067; HoxA13_N.
DR PANTHER; PTHR45804:SF5; HOMEOBOX PROTEIN HOX-C13; 1.
DR PANTHER; PTHR45804; SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF12284; HoxA13_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 259..319
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 261..320
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 23..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 331 AA; 35407 MW; 0356810288FB78D2 CRC64;
MTTSLLLHPR WPESLMYVYE DSAAESGSGG GGGGGGGGGA GGAGGGCSGA SPGKAPSMDG
LGSSCPASHC RDLLPHPVLG RPPAPLGAPQ GAVYTDIPAP EAARQCAPPP APPTSSSATL
GYGYPFGGSY YGCRLSHNVN LQQKPCAYHP GDKYPEPSGA LPGDDLSSRA KEFAFYPSFA
SSYQAMPGYL DVSVVPGISG HPEPRHDALI PVEGYQHWAL SNGWDSQVYC SKEQSQSAHL
WKSPFPDVVP LQPEVNSYRR GRKKRVPYTK VQLKELEKEY AASKFITKEK RRRISATTNL
SERQVTIWFQ NRRVKEKKVV SKSKAPHLHS T
//
