ID A0A2Y9FMQ1_PHYMC Unreviewed; 1245 AA.
AC A0A2Y9FMQ1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Insulin receptor substrate 1 {ECO:0000313|RefSeq:XP_007127060.2};
GN Name=IRS1 {ECO:0000313|RefSeq:XP_007127060.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007127060.2};
RN [1] {ECO:0000313|RefSeq:XP_007127060.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007127060.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007127060.2; XM_007126998.4.
DR AlphaFoldDB; A0A2Y9FMQ1; -.
DR STRING; 9755.ENSPCTP00005016702; -.
DR Ensembl; ENSPCTT00005018422; ENSPCTP00005016702; ENSPCTG00005011909.
DR KEGG; pcad:102992290; -.
DR InParanoid; A0A2Y9FMQ1; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000248484; Chromosome 2.
DR GO; GO:0005901; C:caveola; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
DR GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
DR GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF11; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|RefSeq:XP_007127060.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 12..115
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 160..264
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 120..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..895
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1245 AA; 131154 MW; F96700220AD1BA9E CRC64;
MASPPETDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKGH
HDGAAAPGAG GGGASCSGSS GLGEAGEDLS YGDAPPGPAF KEVWQVILKP KGLGQTKNLI
GIYRLCLTSK TISFVKLNSE AAAVVLQLMN IRRCGHSENF FFIEVGRSAV TGPGEFWMQV
DDSVVAQNMH ETILEAMRAM SDEFRPRSKS QSSSNCSNPI SVPLRRHHLN NPPPSQVGLT
RRSRTESITA TSPASLVGGK QGSFRVRASS DGEGTMSRPA SVDGSPVSPS TNRTHAHRHR
GSSRLHPPLN HSRSIPMPSS RCSPSATSPV SLSSSSTSGH GSTSDCLFPR RSSASVSGSP
SDGGFISSDE YGSSPCDFRS SFRSVTPDSL GHTPPARGEE ELSNYICMGG KGASTLTAPN
GHYILPRSGN GHRYIPAAGL GTSPALTGDE AASAADLDNR FRKRTHSAGT SPTISHQKTP
SQSSVASIEE YTEMMPAYPP GGGTGGRVPS YRHSAFVPTH SYPEEGLEMH PLERRVGHHR
PDTSNLHTDD GYMPMSPGVA PVPGSRKGSA DYMPMSPKSV SAPQQIINPI RRHPQRVDPN
GYMMMSPSGS CSPDIGGGPS SGGSSSGVAP SGSSYGKLWT NGVGGHHSHA LPHPRLPVES
SSGKLLSCTG GYMNMSPVGD SNTSSPSDCY CGPEDPQHKP VLSYYSLPRS FKHTQRPGEL
EEGARHQHLR LSSSSGRLLY AAAAEDSSSS TSSDSLGGGF CAARPEPGLP HLHHQVLQPH
LPRKVDTAAQ TNSRLARPTR LSLGDPKAST LPRAREQQPP PPPPPLLPPP EPKSPGEYVN
IEFGSDQPGY LSGPGASHSS PSVRCPSQLQ PAPREEETGA EEYMNMDLGP GRRAAWRESP
GVQPGSMGPA PAGAASVCRP TRAVPSSRGD YMTMQMGCPR QSYVDTSPVA PISYADMRAG
GGVVVEEASL LGAAAAAPSS SSTASASPAG PQAAEELTAR PSLLGGPQGP GGPSAFTRVN
LSPNRNPSAK VIRADPQGCR RRHSSETFSS TPSATRAGNT VPFGGGAAAG GGGGGSSTED
VKRHSSASFE NVWLRPGELG GAPKELAQVC GAAGGLENGL NYIDLDLVKD FNQSPQERPA
QPQPPPPPPP HQSLGRSESG STSRSSEDLS AYASISFQKP PEDLQ
//
