ID A0A2Y9FNJ8_PHYMC Unreviewed; 2644 AA.
AC A0A2Y9FNJ8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ATR {ECO:0000313|RefSeq:XP_007126551.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007126551.2};
RN [1] {ECO:0000313|RefSeq:XP_007126551.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007126551.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR RefSeq; XP_007126551.2; XM_007126489.4.
DR STRING; 9755.ENSPCTP00005000139; -.
DR Ensembl; ENSPCTT00005000143; ENSPCTP00005000139; ENSPCTG00005000113.
DR KEGG; pcad:102979131; -.
DR InParanoid; A0A2Y9FNJ8; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000248484; Chromosome 1.
DR GO; GO:0070310; C:ATR-ATRIP complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0090734; C:site of DNA damage; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035979; F:histone H2AXS139 kinase activity; IEA:Ensembl.
DR GO; GO:0032405; F:MutLalpha complex binding; IEA:Ensembl.
DR GO; GO:0032407; F:MutSalpha complex binding; IEA:Ensembl.
DR GO; GO:0071480; P:cellular response to gamma radiation; IEA:Ensembl.
DR GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0097694; P:establishment of RNA localization to telomere; IEA:Ensembl.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:Ensembl.
DR GO; GO:0051081; P:nuclear membrane disassembly; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
DR GO; GO:1904884; P:positive regulation of telomerase catalytic core complex assembly; IEA:Ensembl.
DR GO; GO:0070198; P:protein localization to chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0090399; P:replicative senescence; IEA:Ensembl.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_007126551.2};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REPEAT 808..842
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1643..2188
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2296..2604
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2612..2644
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 424..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2644 AA; 301861 MW; E7E14D7F4580DBF7 CRC64;
MGEHGLELAS MIPALRELGS SSPEEYNTVV QKPRQILCQF IDRILTDVNV VALELVKKTD
SQPTSVMLLD FIQHIMKSSP LMFVNVNGSH GQTEAKGSCI EFSNWIITRL LRIAATPSCH
MLHKKICEVI CSLLFLFKSK SPAIFGVVTK ELLHLFEDLI YLHERDAMGH FVEWPVVVSR
FLSHLDEHVG YLQPAPLQFM NMQNLEFIEV TLLTVLIRII AIVFFRRQEL LLWRIVCVLL
EYGSPKVKSL AISLLTELFE LGGLPAQPAS TFFSSFLELL KHLVEMDADQ LKLYEEPLSK
LIKTLFPFEA EAYRNVEPVY LNMLLEKLCV MFEDGVLMQL KSDLLKAALC HLLQYFVRYV
PAGYESALQV RKVHVRNICR ALVDVLGVQV DTEYLLGPLY AALKMESMEI IEEVQCQIQQ
ENLSSNSDGL SPKRRRLSSS LNSSKRAPKQ TEEIKHVDMN KKSILWSALI QKAESLQVFL
EFNNLKNPVI ETLEGIAVIL QLTALCTVHC SHQNMACCCD FKDCQQKCKK PSVVITWISL
DFYTKVLKSC RTLLESVQKP DLETIIDKVV KIYDALMYIQ VKTSFEDHIL EDLCGMLSLP
WICSHSDDGS LKLTTFATSL LTLSQRISDS YSPQAQSRCV FLLTLFPRRI YLEWRTAVYS
WALQSSHEVI RTSCINGFFI LLQQQNSCNR VPKILIDKVK DDSDIVKKEF ASILGQLVCT
LHGMFYLTSC LSEPFSEHRR IDLLCKSLKV TSQHECSSSR LKVSVCKPFL FLLKKKLPSP
VKLAFIDNLY HLCKHLDFRE DETHVKMVLG TLLNLMEDPD KDVRVAFSGN IKHILESLDA
EDGFIKELFV LRMKEAYTHA QISRNNELKD TLILTTGDIG RAAKGDLVPF ALLHLLHCLL
SKSASVSGAA YTEIRALVAA KSVKLQNFFS QYKKPICQFL VESLHSSQMT VLPSTPCQNA
EMRKQDVAHQ REMALNTLSE IANVFDFPDL NRFLTRTLQV LLPDLAAKAS PAASALIRTL
GKQLNVNRRE ILINNFKYIF SHLVCSCSKD ELERALHYLK NETEIELGSL LRQDFQGLHN
ELLLRIGEHY QQVFNGLSIL ASFASSDDPY QGPRDITSPE LMADYLQPKL LGILAFFNMQ
LLSSSVGIED KKMALNSLMS LMKLMGPKHV SSVRVKMMTT LRTGLRFKDD FPELCCRAWD
CFVRCLDHAY LGSLLSHVIV ALLPLIHIQP KETAAIFHYL IIENRDAVQD FLHEIYFLPD
HPEFKKIKEV LQEYRKETSE STDLQTTLQL SMKAIQHENV DVRIHALTSL KETLYKNQEK
LIRYATDSET VEPVISQLVT VLLKGCQDAN SQARLLCGEC LGELGAIDPG RLDFSTTETQ
GKDFTFVTGV EDANFAYGLL MELTRAYLAY ADNSRAQDSA AYAIQELLSI YDCREMQTDG
PGHQLWRRFP EHVREILEPH LNTRYKSSQK STDWSGVKKP IYLSKLGNNF AEWSASWAGY
LITKVRHDLA SKIFTCCSIM MKHDFKVTIY LLPHILVYVL LGCNQEDQQE VYAEIMAVLK
HDDQHTISTQ DSASDLCQLS TQTVFSMLDH LTQWARHKFQ ALNAEKFPHG KSNRDKVDSM
IPTVDYEDYQ SVTRFLDLIP QDTLAVASFR SKAYTRAVMH FESFITEKKQ NIQEHLGFLQ
KLYAAMHEPD GVAGVSTIRK AEPSLKEQIL EHESIGLLRD ATACYDRAIQ LEPDQIIHYH
GVVKSMLGLG QLSTVITQVN GVHANRSEWT DELNTYRVEA AWKLSQWDLV ENYLAADGKS
TTWSVRLGQL LLSAKKKDIT AFYDTLKLVR AEQIVPLSAA SFERGSYQRG YEYIVRLHML
CELEHSVKPL FHQSPGDSTQ EDSLNWVARL EMTQNSYRAK EPILALRRAL LSLNKRPDYK
EMVGECWLQS ARVARKAGHH QTAYNALLNA GESRLAELYV ERAKWLWSKG DVHQALIVLQ
KGVELCFPEN KTPAESKNML IHGRAMLLVG RFMEETANFE SNAVMKKYKD VTLFLPEWED
GHFYLAKYYD KLMPMVTDNK MEKQGDLIRY IVLHFGRSLQ YGNQFIYQSM PRMLSLWLDF
GAKAYEWEKA GRSDRVQMRN DLAKINKVIT EHTNHLAPYQ FLTAFSQLIS RICHSHDEVF
VVLMEIIAKV FLAYPQQAMW MMTAVSKSSY PMRVNRCKEI LNKAIHMKKS LEKFVGDATR
LTDKLLELCN KSVDGSSSTL SMSTHFKMLK KLVEEATFSE ILIPLQSVMI PTLPSVPGAH
ANHEPFPGHW AYIAGFDDTV EILASLQKPK KISLKGSDGK FYIMMCKPKD DLRKDCRLME
FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY
MTGKELRQCM LPKSAALSEK LKVFREFLLP RHPPVFHEWF LRTFPDPTSW YSSRSAYCRS
TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN KGETFEVPEI VPFRMTHNMV
NGMGPMGTEG LFRRACEVTM RLMRDQREPL MSVLKTFLHD PLVEWSKPVK GHSKAPLNET
GEVVNEKAKT HVLDIEQRLQ GVIKTRNRVT GLPLSIEGHV HYLIQEATDE NLLCQMYLGW
TPYM
//
