ID A0A2Y9FQF0_PHYMC Unreviewed; 665 AA.
AC A0A2Y9FQF0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Rho GTPase-activating protein 18 isoform X2 {ECO:0000313|RefSeq:XP_007128445.1};
GN Name=ARHGAP18 {ECO:0000313|RefSeq:XP_007128445.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007128445.1};
RN [1] {ECO:0000313|RefSeq:XP_007128445.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007128445.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007128445.1; XM_007128383.4.
DR AlphaFoldDB; A0A2Y9FQF0; -.
DR STRING; 9755.ENSPCTP00005009883; -.
DR Ensembl; ENSPCTT00005010926; ENSPCTP00005009883; ENSPCTG00005006989.
DR GeneID; 102981110; -.
DR CTD; 93663; -.
DR OrthoDB; 11483at2759; -.
DR Proteomes; UP000248484; Chromosome 10.
DR GO; GO:0005881; C:cytoplasmic microtubule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:2000145; P:regulation of cell motility; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF6; RHO GTPASE-ACTIVATING PROTEIN 18; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 326..525
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 17..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 75006 MW; 1E6F82C965CBD756 CRC64;
MSWLSSSQGV VLTAYHPSGK DQALGGNHGK GGEEATTSRR YGQYTMNQEI TKVMERPPFD
RSSSQDSLDE LSMEDYWTEL ENIKKSSENR QEDQEVVVVK EPDEGELEEE WLKEAGLSNL
FGEAAGDPQE SMVFLSTLTR TQAAAVQKRV ETVSQTLRKK NKQYQVPDVR DIFAQQRGSK
EREPPDGTES QSVRTEENKY QGKDDQASSL AVGKKELTPL VPEEAPASET DINLEVSFAE
QAVNQKESSR EKIQRSKGDD ALLPSFRLPK DKTGTTKIGD LAPQDMKKVC HLALIELTAL
YDVLGVELKQ LKAVKIKTKD SGLFCVPLTV LLEQDQKKVP GTRIPLIFQK LISCIEEGGL
ETEGLLRIPG AAVRIKNLCQ ELEAKFYEGT FNWESVKQHD AASLLKLFIR ELPQPLLSVE
YLKAFQAVQN LPTKKQQLQA LNLLVILLPD ANRDTLKALL EFLQRVVDNK EKNKMTVMNV
AMVMAPNLFM YHTLGLKSSE QREFVMAAGI ANIMHLLIKY QKLLWTIPKF IVNQVRKQNT
ENHRKDKKAM KKLLKKMAYD REKYEKQDKS ANDADVPQGV IRVQAPHLSK VSMAIQLTEE
LRASDVLARF LSQESGVAQT LKNGEVFLYE IGGNIGERCL DDDTYMKDLY QLNPNAEWVI
KSKPS
//
