ID A0A2Y9FRC4_PHYMC Unreviewed; 1552 AA.
AC A0A2Y9FRC4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Nuclear factor of activated T-cells 5 isoform X2 {ECO:0000313|RefSeq:XP_007129093.2};
GN Name=NFAT5 {ECO:0000313|RefSeq:XP_007129093.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007129093.2};
RN [1] {ECO:0000313|RefSeq:XP_007129093.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007129093.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007129093.2; XM_007129031.4.
DR Proteomes; UP000248484; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 282..461
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 56..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1337..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1494..1524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 168004 MW; DDFE8A58014624BC CRC64;
MPSDFISLLS ADLDLESPKS LYSRDSLKLH PSQNFHRAGL LEESVYDLLP KELQLPPSRE
PSVASMSQTS GGEAGSPPPA VVAADASSAP SSSSMGGACS SFTTSSSPTI YSTSVTDSKA
MQVESCSSAL GVSNRGVSEK QLTSNTVQQH PSTPKRHTVL YISPPPEDLL DNSRMSCQDE
GCGLESEQSC SMWMEDSPSN FSNMSTSSYN DNTEVPRKSR KRNPKQRPGV KRRDCEESNM
DIFDADSAKA PHYVLSQLTT DNKGNSKAGN GTLENQKGTG VKKSPMLCGQ YPVKSEGKEL
KIVVQPETQH RARYLTEGSR GSVKDRTQQG FPTVKLEGHN EPVVLQVFVG NDSGRVKPHG
FYQACRVTGR NTTPCKEVDI EGTTVIEVGL DPNNNMTLAV DCVGILKLRN ADVEARIGIA
GSKKKSTRAR LVFRVNITRK DGSTLTLQTP SSPILCTQPA GVPEILKKSL HSCSVKGEEE
VFLIGKNFLK GTKVIFQENV SDENSWKSEA EIDMELFHQN HLIVKVPPYH DQHITLPVSV
GIYVVTNAGR SHDVQPFTYT PDPAAAALNV NVKKEISSPA RPCSFEEAMK AMKTAGCNLD
KVNILPNALI TPLISSSVIK SEDVTPMEVT AEKRSSPIFK TTKTVGSTQQ TLENISNIAG
NGSFSSSSSS SHLPSENEKQ QQIQPKAYNP ETLTTIQTQD ISQPGTFPAV SASSQLPNSD
ALLQQATQFQ TRETQSREVL QSDGTVVNLS HLTEASQQQQ QSPLQEQAQT LQQQISSNIF
PSPNSVSQQL QNTIQQLQAG SFTGSTTSGS NGNVDLVQQV LEAQQQLSSV LFSAPDGNEN
VQEQLSADIF QQVSQIQNSV SPGMFSSTEP AVHTRPDNLI AGRAESVHPQ NENTLSNQQQ
QQQQQQVMES SAAMVIEMQQ SICQAAAQIQ SELFPSTASA NGNLQQSPVY QQTSHMMSAL
SANEDMQMQC ELFSSPPAVS GNETATTTTQ QVATPGTTMF QTSSSADGEE TGAQAKQIQN
SVFQTMVQMQ HSGDSQPQVS LFSSTKSMIS VQNNGTQQQG NGLFQQGNEM MSLQSGNFLQ
QSSHSQAQLF HPQNPIADAQ NLSQETQGSI FHSPSPIVHS QTSTTSSEQM QPAMFHSQNT
MAVLQGSSVP QDQQSANIFL SQSPMNNLQT NTVAQEEQIS FFAAQNSISP LQSTSNSEQQ
AAFQQQAPIS HIQTPMLSQE QAQPSQQGLF QPQVSLGSLP PNPMPQNQQG AIFQSQHSMV
AIQSNSASQE QQQQQQQQQQ QQQQQQQSIL FSSQNTMAPM ASQKQPPPNM IFNPSQNPMA
NQEQQNQSIF HQQNNMAPMS QEQQPMQFQN QPTVSSLQNP GPAQSESSQT SLFHSSPQIQ
LVQGSPSSQE QQVTLFLSPA SMSALQNSIN QQDMQQSPLY SPQNNMPGIQ GATSSPQPQA
ALFHNTTGGT MNQLQNSPGS SQQTSGMFLF GIQNNCSQLL TSGPATLPDQ LMAISQPGQP
QNEGQPPVTT LLSQQMPESS PLASSINTSQ NIEKIDLLVS LQNQGNNLTG SF
//
