ID   A0A2Y9FU11_PHYMC        Unreviewed;       899 AA.
AC   A0A2Y9FU11;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 2 isoform X5 {ECO:0000313|RefSeq:XP_007129063.1};
GN   Name=NFATC2 {ECO:0000313|RefSeq:XP_007129063.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007129063.1};
RN   [1] {ECO:0000313|RefSeq:XP_007129063.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007129063.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007129063.1; XM_007129001.4.
DR   AlphaFoldDB; A0A2Y9FU11; -.
DR   Ensembl; ENSPCTT00005007705; ENSPCTP00005007009; ENSPCTG00005004813.
DR   GeneID; 102993777; -.
DR   KEGG; pcad:102993777; -.
DR   CTD; 4773; -.
DR   OrthoDB; 5405363at2759; -.
DR   Proteomes; UP000248484; Chromosome 14.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd01178; IPT_NFAT; 1.
DR   CDD; cd07881; RHD-n_NFAT; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR008366; NFAT.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR12533; NFAT; 1.
DR   PANTHER; PTHR12533:SF4; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR01789; NUCFACTORATC.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          366..548
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
FT   REGION          55..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          813..868
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..851
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   899 AA;  97347 MW;  2C5E0C4E76975F1F CRC64;
     MQREAAFRLG HCHPLRIMGS VDQEEPNAHK VASPPSGLAY PDDVLDYGLK PYSPLASLSG
     EPSRRLGEPD RVGPQNFLCP AKPAGASGLS PRIEITPSHE LMQAGGPFRV RDTGLLVEQP
     PLPGVAASPR FTLPVPGFEG YREPLCLSPA SSGSSASFIS DTFSPYTSPC VSPNNGGPDD
     LCPQFQNIPA HYSPRTSPIM SPRTGLAEDS CLGRHSPVPR PASRSSSPGT KRRHSCTGAL
     VAPLPGASPQ RSRSPSPQPR DDGAPAGYPP TAGSAVLMDA LNSLAADSPC GIPSKMWKTS
     PDPSPVSTAP SKAGLPRHIY PAVEFLGPCE QEERRNSAPE SILLVPPTWP KQLVPAIPIC
     SIPVTASLPP LEWPLSHQSG SYELRIEVQP KPHHRAHYET EGSRGAVKAP TGGHPVVQLH
     GYMENKPLGL QIFIGTADER ILKPHAFYQV HRITGKTVTT TSYEKIVGNT KVLEIPLEPK
     NNMRATIDCA GILKLRNADI ELRKGETDIG RKNTRVRLVF RVHIPESSGR IVSLQTASNP
     IECSQRSAHE LPMVERQDID SCLVYGGQQM ILTGQNFTAE SKVVFTEKTT DGQQIWEMEA
     TVDKDKSQPN MLFVEIPEYR NKHIRTSVKV NFYVINGKRK RSQPQHFTYH PVPAIKTEPT
     DEYDPTLICS PAHGGLGSQP YYPQHPMVAE SPSCLVATMA PCQQFRSGLS SPDARYQQQS
     PAAVLYQRSK SLSPSLLGYQ QPALMAAPLS LADAHCSVLV HAGSQGQSSA LLHSSPANQQ
     ASAVIHCSPT NQQLRCGSHQ EFQHIVYCEN FAPGTTRPGP PPASQGQRLS PGSYPTVIQQ
     QNATSQRAAK NGPPVGDQKE VLPAGVTIKQ EQNLDQTYLD DVNEIIRKEF SGPPARNQT
//