ID A0A2Y9FVY8_TRIMA Unreviewed; 159 AA.
AC A0A2Y9FVY8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Prorelaxin-like {ECO:0000313|RefSeq:XP_012410150.1};
GN Name=LOC101355943 {ECO:0000313|RefSeq:XP_012410150.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_012410150.1};
RN [1] {ECO:0000313|RefSeq:XP_012410150.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR RefSeq; XP_012410150.1; XM_012554696.1.
DR AlphaFoldDB; A0A2Y9FVY8; -.
DR STRING; 127582.A0A2Y9FVY8; -.
DR GeneID; 101355943; -.
DR KEGG; tmu:101355943; -.
DR InParanoid; A0A2Y9FVY8; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04365; IlGF_relaxin_like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022421; Relaxin.
DR PANTHER; PTHR12004:SF13; PRORELAXIN H2; 1.
DR PANTHER; PTHR12004; RELAXIN; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02004; RELAXIN.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..159
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016050499"
FT DOMAIN 32..159
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 51..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 159 AA; 17989 MW; F5428C35BC3DF8C0 CRC64;
MPRPLLFRLL GVCLLLSQLP RELSAQQSST VKKLCGHELV RARKEACSKT HWGMGGSKGK
PSLKTHEAPD LEPSSIKKDA KTTNEFLEFT PDIHKKVTEN EKFSRKNPKI QSEAEDNSLP
ETESLSLDQH SRKKKMLSKL LRRKCCKKGC TMKELSRAC
//
