ID A0A2Y9FZ05_TRIMA Unreviewed; 921 AA.
AC A0A2Y9FZ05;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=LOC101346767 {ECO:0000313|RefSeq:XP_012413019.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_012413019.1};
RN [1] {ECO:0000313|RefSeq:XP_012413019.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012413019.1; XM_012557565.1.
DR AlphaFoldDB; A0A2Y9FZ05; -.
DR STRING; 127582.A0A2Y9FZ05; -.
DR GeneID; 101346767; -.
DR KEGG; tmu:101346767; -.
DR InParanoid; A0A2Y9FZ05; -.
DR OrthoDB; 2971005at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08801; Death_UNC5D; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR042058; UNC5D_Death.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 33..921
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5025094817"
FT TRANSMEM 348..371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 134..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 510..650
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 921 AA; 102036 MW; 152D6A0A07DFFA93 CRC64;
MARAAAAGGG GGGARRWLPW LGLCFWAAGA AAARGTDNGE VLPESIPSAP GTLPHFIEEP
DDAYIIKSNP IALRCKARPA MQIFFKCNGE WVHQNEHVSE ESLDESSGKR VVKVFINNKK
QLLDLRKNFE QDPQGREVPI EGMIVLHCRP PEGVPAAEVE WLKNEEPIDS EQDENIDTRA
DHNLIIRQAR LSDSGNYTCM AANIVAKRRS LSATVVVYVN GGWSSWTEWS ACNVPCGRGW
QKRSRTCTNP APLNGGAFCE GMSVQKITCT SLCPVDGSWE VWSEWSVCSP ECEHLRIREC
TAPPPRNGGK FCEGLSQESE NCTDGLCILD KKPLHEIKPQ SIENASDIAL YSGLGAAVVA
VAVLVIGVTL YRRSQSDYGV DVIDSSALTG GFQTFNFKTV HQGNSLLLNS SMQPDLTVSR
TYSGPICLQD PLDKELMTES SLFNPLSDIK VKVQSSFMVS LGVSERAEYH GKNHSGTFPH
GNNRSFSTMH PRNRTPYIQN LSSLPTRTEL RTTGVFGHLG GRLVMPNTGV SLLIPHGAIP
EENSWEIYMS INQGEPSLQS DGSEVLLSPE VTCGPPDMIV TTPFALTIPH CADVSSEHWN
IHLKKRTQQG KWEEVMSVED ESTSCYCLLD PFACHVLLDS FGTYALTGEP ITDCAVKQLK
VAVFGCMSCN SLDYNLRVYC VDNTPCAFQE VVSDERHQGG QLLEEPKLLH FKGNTFSLQI
SVLDIPPFLW RIKPFTACQE VPFSRVWCSN RQPLHCAFSL ERYTPTTTQL SCKICIRQLK
GHEQILQVQT SILESERETI TFFAQEDSTF PAQTGPKAFK IPYSIRQRIC ATFDTPNAKG
KDWQMLAQKN SINRNLSYFA TQSSPSAVIL NLWEARHQHD GDLDSLACAL EEIGRTHMKL
SNITESQLDE ADFNYSRQNG L
//
