ID A0A2Y9FZH9_TRIMA Unreviewed; 343 AA.
AC A0A2Y9FZH9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Triacylglycerol lipase {ECO:0000256|RuleBase:RU362046};
DE EC=3.1.1.3 {ECO:0000256|RuleBase:RU362046};
DE AltName: Full=Pancreatic lipase {ECO:0000256|RuleBase:RU362046};
GN Name=LOC101348761 {ECO:0000313|RefSeq:XP_012410558.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_012410558.1};
RN [1] {ECO:0000313|RefSeq:XP_012410558.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC Evidence={ECO:0000256|RuleBase:RU362046};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU362046}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR RefSeq; XP_012410558.1; XM_012555104.1.
DR AlphaFoldDB; A0A2Y9FZH9; -.
DR STRING; 127582.A0A2Y9FZH9; -.
DR GeneID; 101348761; -.
DR KEGG; tmu:101348761; -.
DR InParanoid; A0A2Y9FZH9; -.
DR OrthoDB; 3428256at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR002331; Lipase_panc.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610:SF108; INACTIVE PANCREATIC LIPASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR11610; LIPASE; 1.
DR Pfam; PF00151; Lipase; 1.
DR Pfam; PF01477; PLAT; 1.
DR PRINTS; PR00823; PANCLIPASE.
DR PRINTS; PR00821; TAGLIPASE.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|RuleBase:RU362046};
KW Lipid degradation {ECO:0000256|RuleBase:RU362046};
KW Lipid metabolism {ECO:0000256|RuleBase:RU362046};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU362046}.
FT DOMAIN 223..343
FT /note="PLAT"
FT /evidence="ECO:0000259|SMART:SM00308"
SQ SEQUENCE 343 AA; 38146 MW; 540D021ABA9FE98E CRC64;
MSTMILLPSE PSTIDASNFQ MDRKTRFIIH GFIDKRDESW LLDMCKNMFQ VEEVKCICVD
WRRCSQTSFT QEANKVQVVG TQVAQMLSVL LMSQTNYSYS PSNVHLIGHS LGAHVAGEAG
SGTPGLDRIT GLGPIEASFR GTPEEVRLDP SDAVFVDVIH TDAAHLIPFL GFGTNQLVGH
TDFFPQGGEE MPEYEKALSQ IIDLDGIWTG TQDFVACNHL RSYKYYSESI LNPNGFAVYP
CAFLGTVPLQ GCCPPMFGEC FYFSISRGIM MPSSTHSYEF DAKLYVGTIE KVKFLWHNNV
VNATFRKVGA AKITVQKGEE KTVYNFCSEG TVKEDMLLTL TPC
//
