ID A0A2Y9G191_TRIMA Unreviewed; 346 AA.
AC A0A2Y9G191;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta {ECO:0000256|RuleBase:RU362099};
GN Name=LOC101343098 {ECO:0000313|RefSeq:XP_012411941.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_012411941.1};
RN [1] {ECO:0000313|RefSeq:XP_012411941.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act as a transcriptional coregulator during muscle
CC development through its interaction with SNW1. Has lost its ancestral
CC function as a Na,K-ATPase beta-subunit.
CC {ECO:0000256|ARBA:ARBA00037398}.
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane.
CC {ECO:0000256|RuleBase:RU362099}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. Nucleus
CC inner membrane {ECO:0000256|ARBA:ARBA00037816}; Single-pass type II
CC membrane protein {ECO:0000256|ARBA:ARBA00037816}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000256|ARBA:ARBA00005876, ECO:0000256|RuleBase:RU362099}.
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DR RefSeq; XP_012411941.1; XM_012556487.2.
DR AlphaFoldDB; A0A2Y9G191; -.
DR GeneID; 101343098; -.
DR OrthoDB; 2880589at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR NCBIfam; TIGR01107; Na_K_ATPase_bet; 1.
DR PANTHER; PTHR11523:SF12; PROTEIN ATP1B4; 1.
DR PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU362099};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362099};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362099};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362099}; Transport {ECO:0000256|RuleBase:RU362099}.
FT TRANSMEM 100..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362099"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 346 AA; 40244 MW; D07A01232DD53DFF CRC64;
MRQQLRSRRA PTFPHGYRYR LDDQDEVNQN YLADEEEEAE EEARVMRVPN LEEEEKEEEQ
KEEEEGQGQP TGNTWWQKLQ LMNEYLWDPE QRMSLARTGL ILVIYFFFYA SLAAVITVCM
YTLFLTISAY MPTFTERVKP AGVMIRPFAH SLNFNFNVSE PDTWQHYVIS LNGFLQGYND
SLQEEMNVDC PPGQYFIQDG NEDEDKKACQ FKRSFLKNCS GLEDPTFGYS TGQPCILLKM
NRIVGFRPEL GDPVKVSCKV QRGDENDIRS IHYYPESASF DLRYYPYYGK LTHVNYTSPL
VAMHFTDVVK NQAVPVQCQL KGKGIINDVI NDHFVGRVIF TLNIET
//
