ID A0A2Y9G1M7_TRIMA Unreviewed; 673 AA.
AC A0A2Y9G1M7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Ammonium transporter Rh type C {ECO:0000256|ARBA:ARBA00041036};
DE AltName: Full=Rhesus blood group family type C glycoprotein {ECO:0000256|ARBA:ARBA00042618};
GN Name=LOC101351464 {ECO:0000313|RefSeq:XP_012415095.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_012415095.1};
RN [1] {ECO:0000313|RefSeq:XP_012415095.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526;
CC Evidence={ECO:0000256|ARBA:ARBA00036376};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74892;
CC Evidence={ECO:0000256|ARBA:ARBA00036376};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747,
CC ChEBI:CHEBI:28938; Evidence={ECO:0000256|ARBA:ARBA00036550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28748;
CC Evidence={ECO:0000256|ARBA:ARBA00036550};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28749;
CC Evidence={ECO:0000256|ARBA:ARBA00036550};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391,
CC ChEBI:CHEBI:59338; Evidence={ECO:0000256|ARBA:ARBA00036492};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:74392;
CC Evidence={ECO:0000256|ARBA:ARBA00036492};
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000256|ARBA:ARBA00011036}.
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DR RefSeq; XP_012415095.1; XM_012559641.1.
DR AlphaFoldDB; A0A2Y9G1M7; -.
DR STRING; 127582.A0A2Y9G1M7; -.
DR GeneID; 101351464; -.
DR KEGG; tmu:101351464; -.
DR InParanoid; A0A2Y9G1M7; -.
DR OrthoDB; 5483564at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR InterPro; IPR002229; RhesusRHD.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF30; AMMONIUM TRANSPORTER RH TYPE C; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 474..511
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT REGION 512..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 72379 MW; 8EF74D6433D4F5FC CRC64;
MTWNTNLRWR LPLICLLLEV VMVVLFGVFV RYDYEADAHW PEERRHRNIV SDSENDFYYR
YPSFQDVHVM IFVGFGFLMT FLQRYGFSAV GFNFLLAAFG IQWALLMQGW FHAFQDGYIV
IGVESLINAD FCVGSVCVAF GALLGKVSPI QLLIMTLFQV TLFTVNEFIL LNLLLVKDAG
GSMTIHTFGA YFGLTVTWVL YRPNLQQSKE RQSSVYHSDL FAMIGTLFLW MYWPSFNSAV
SNHGDAQHRA VINTYCSLAA CVLTSVALSS ALQKKGKLDM VHIQNATLAG GVAVGTAGEM
MLMPYGSVIV GCISGIVSTL GFVYLTPFLE AHLQIQDTCG IHNLHGMPGL IGGIVGAVTA
AYANSEVYGH EGLVQAFDFE GSNSNRTTQL QGSFQAAGIF VSLAMALVGG GIVGIILKLP
CWGQPADENC FEDKIYWEAR PSLPPSPPLS LPTSLPLCPA AVSTVDGAAK PPTYPQLSRI
CGSDRATVPV WDAGVSGVDL NHRAPQCGVW IPGAPSAGGS GEGASGGEGQ RTAGPTDEET
TRVNWAEERE RGARPGLAEV APPARFPSPF LGESQRAQMR GEGWGWSEHT QGLPLAAGKR
EPVGLSVSIC DAGEGGPLAA KGLQGEALVR AGTSRLVAKA SLRWFLRVGA QPRASVGEGR
CSRNPPGVGT EAL
//
