ID A0A2Y9G3G9_NEOSC Unreviewed; 334 AA.
AC A0A2Y9G3G9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Procathepsin L {ECO:0000313|RefSeq:XP_021533572.1, ECO:0000313|RefSeq:XP_021533573.1};
GN Name=LOC110569925 {ECO:0000313|RefSeq:XP_021533572.1,
GN ECO:0000313|RefSeq:XP_021533573.1, ECO:0000313|RefSeq:XP_044776722.1};
OS Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Neomonachus.
OX NCBI_TaxID=29088 {ECO:0000313|Proteomes:UP000248481, ECO:0000313|RefSeq:XP_021533572.1};
RN [1] {ECO:0000313|RefSeq:XP_021533572.1, ECO:0000313|RefSeq:XP_021533573.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_021533572.1,
RC ECO:0000313|RefSeq:XP_021533573.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_021533572.1; XM_021677897.1.
DR RefSeq; XP_021533573.1; XM_021677898.1.
DR RefSeq; XP_044776722.1; XM_044920787.1.
DR STRING; 29088.A0A2Y9G3G9; -.
DR KEGG; nsu:110569925; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000248481; Chromosome 13.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF57; CATHEPSIN L2; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000248481};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..334
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041069132"
FT DOMAIN 29..88
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 114..333
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 334 AA; 37206 MW; 19A0DA2028AF8AAA CRC64;
MNPSFFLAAL CLGIAAAAPK LDQSLDAHWS QWKAAHRRLY GMNEEGWKRA VWEKNMKMIE
LHNREYSQGK HGFTMAMNAF GDMTNEEFRQ VMNGFRNQKH RKGKVFQEPL FAAIPKSVDW
TLKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RSQGNEGCSG
GLMDYAFQYV KDNGGLDSEE SYPYLARDTD TCNYRPECSA ANDTGFVDIP QREKALMKAV
ATVGPISVAI DAGHQSFQFY KSGIYFDPEC SSKDLDHGVL VVGYGYEGTD SNNNKFWIVK
NSWGPEWGCN GYVKMAKDQD NHCGIATAAS YPIV
//
