ID A0A2Y9G474_TRIMA Unreviewed; 1239 AA.
AC A0A2Y9G474;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase T {ECO:0000313|RefSeq:XP_012414133.1};
GN Name=LOC101353284 {ECO:0000313|RefSeq:XP_012414133.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_012414133.1};
RN [1] {ECO:0000313|RefSeq:XP_012414133.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_012414133.1; XM_012558679.1.
DR AlphaFoldDB; A0A2Y9G474; -.
DR STRING; 127582.A0A2Y9G474; -.
DR GeneID; 101353284; -.
DR KEGG; tmu:101353284; -.
DR InParanoid; A0A2Y9G474; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF8; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 4.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_012414133.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 627..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..165
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 167..258
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 265..358
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 363..457
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 460..563
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 769..990
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 908..981
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1022..1239
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1195..1239
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 670..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1239
FT /evidence="ECO:0000313|RefSeq:XP_012414133.1"
SQ SEQUENCE 1239 AA; 138992 MW; 4AF5DA8F03942359 CRC64;
MFTGGCSFDE HYSNCGYSVA LGTNGFTWEQ INTWEKPMLD PAVPTGSFMM VNSSGRASGQ
KAHLLLPTLK ENDTHCIDFH YYFSSRDRSS PGALNVYVKV NGGPQGNPVW NVSGVVTEGW
VKAELAISTF WPHFYQVIFE SVSLKGHPGY IAVDEVRVLA HPCRKAPHFL RLQNVEVNVG
QNATFQCIAG GKWSQHDKLW LQQWNGRDTA LMVTRVVNHR RFSATVSVAD TAQRSVSKYR
CVIRSDGGSG VSNYAELIVK EPPTPIAPPE LLAVGATYLW IKPNANSIIG DGPIILKEVE
YRTTTGTWAE THIVDSPNYK LWHLDPDVEY EIRVLLTRPG EGGTGPPGPP LTTRTKCADP
VHGPQNVEIV DIRARQLTLQ WEPFGYAVTR CHSYNLTVRY QYVFNQQQYE AEEVIQTSSH
YTLRGLRPFM TIRLRLLLSN PEGRMESEEL VVQTEEDVNQ AMALELQKPK FESQIFISWG
PVNESNGVVR YFKINYKAVG SLDPSADLSS QRGKVFKLRN ETHHLFVGLY PGTTYSFTIK
ASTAKGFGPP VTTRIATKIS APSMPEYDTD TPLNETDTTI TVMLKPAQSR GAPETKINCV
RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV IAGLLMFIII LLGVMLTIKR RRNAYSYSYY
LKLAKKQKET QSGAQREMGP VASADKPTAK LSANRNDEGF SSSSQDVNGF TDGSRGELSQ
PTLTIQTHPY LTCDPMEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ
TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG YHRPRHYIAT
QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY WPDDTEVYGD IKVTLIETEP
LAEYVIRTFT VQKVKLFGNP HQAGPIAAHC SNAGAGRTGC FIAIDTMLDM AENEGVVDIF
NCVRELRAQR VNLVQTEEQY VFVHDAILEA CLCGNTAIPV CEFRSLYYNI SRLDPQTNSS
QIKDEFQTLN IVTPRVRPED CSIGLLPRNH DKNRNMDVLP LDRCLPFLIS VDGESSNYIN
AALMDSHKQP AAFVVTQHPL PNTVADFWRL VFDYNCSSVV MLNEMDTAQL CMQYWPEKTS
GCYGPIQVEF VSADIDEDII HRIFRICNMA RGTSSRYCSC GFRINVSSNL ESLNGGGRSG
TFCAICSVCE MIQQQNIIDV FHIVKTLRNN KSNMVETLV
//
