ID A0A2Y9H4I8_NEOSC Unreviewed; 1116 AA.
AC A0A2Y9H4I8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 12 member 5 isoform X2 {ECO:0000313|RefSeq:XP_021544880.1};
GN Name=SLC12A5 {ECO:0000313|RefSeq:XP_021544880.1};
OS Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Neomonachus.
OX NCBI_TaxID=29088 {ECO:0000313|Proteomes:UP000248481, ECO:0000313|RefSeq:XP_021544880.1};
RN [1] {ECO:0000313|RefSeq:XP_021544880.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_021544880.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_021544880.1; XM_021689205.1.
DR AlphaFoldDB; A0A2Y9H4I8; -.
DR Proteomes; UP000248481; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000248481};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..275
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 398..675
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 689..807
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 820..952
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1048..1116
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 123544 MW; 28A777A0CB4097A7 CRC64;
MLNNLTDCED GDGGANPGDG NPKESSPFIN STDTEKGREY DGKNMALFEE EMDTSPMVSS
LLSGLANYTN LPQGSREHEE AENNEGGKKK PVQAPRMGTF MGVYLPCLQN IFGVILFLRL
TWVVGIAGIM EAFCMVFICC SCTMLTAISM SAIATNGVVP AGGSYYMISR SLGPEFGGAV
GLCFYLGTTF AGAMYILGTI EILLAYLFPA MAIFKAEDAS GEAAAMLNNM RVYGTCVLTC
MATVVFVGVK YVNKFALVFL GCVILSILAI YAGVIKSAFD PPNFPICLLG NRTLSRHGFD
VCAKLAWEGN ETVTTRLWGL FCSSRFLNAT CDEYFTRNNV TEIQGIPGAA SGLIKENLWS
SYLTKGVIVE RRGMPSVGLA EGAPVDMDHP YVFSDMTSYF TLLVGIYFPS VTGIMAGSNR
SGDLRDAQKS IPTGTILAIA TTSAVYISSV VLFGACIEGV VLRDKFGEAV NGNLVVGTLA
WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAISRDGIVP FLQVFGHGKA NGEPTWALLL
TACICEIGIL IASLDEVAPI LSMFFLMCYM FVNLACAVQT LLRTPNWRPR FRYYHWTLSF
LGMSLCLALM FICSWYYALV AMLIAGLIYK YIEYRGAEKE WGDGIRGLSL SAARYALLRL
EEGPPHTKNW RPQLLVLVRV DQDQNVVHPQ LLSLTSQLKA GKGLTIVGSV LEGTFLDNHP
QAQRAEESIR RLMEAEKVKG FCQVVISSNL RDGVSHLIQS GGLGGLQHNT VLVGWPRNWR
QKEDHQTWRN FIELVRETTA GHLALLVTKN VSMFPGNPER FSEGSIDVWW IVHDGGMLML
LPFLLRHHKV WRKCKMRIFT VAQMDDNSIQ MKKDLTTFLY HLRITAEVEV VEMHESDISA
YTYEKTLVME QRSQILKQMH LTKNEREREI QSITDESRGS IRRKNPVNTR LRLNVPEETA
GDNEEKAEEE VQLIHDQSAP SCPSSSPSPG EEPEGEGEAD PEKVHLTWTK DKSVAEKNKG
PSPVSSEGIK DFFSMKPEWE NLNQSNVRRM HTAVRLNEVI VKKSRDAKLV LLNMPGPPRN
RNGDENYMEF LEVLTEHLDR VMLVRGGGRE VITIYS
//
