ID A0A2Y9HDG2_NEOSC Unreviewed; 476 AA.
AC A0A2Y9HDG2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Tubulointerstitial nephritis antigen {ECO:0000313|RefSeq:XP_021547750.1};
GN Name=TINAG {ECO:0000313|RefSeq:XP_021547750.1};
OS Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Neomonachus.
OX NCBI_TaxID=29088 {ECO:0000313|Proteomes:UP000248481, ECO:0000313|RefSeq:XP_021547750.1};
RN [1] {ECO:0000313|RefSeq:XP_021547750.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_021547750.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_021547750.1; XM_021692075.1.
DR AlphaFoldDB; A0A2Y9HDG2; -.
DR STRING; 29088.A0A2Y9HDG2; -.
DR KEGG; nsu:110582123; -.
DR InParanoid; A0A2Y9HDG2; -.
DR OrthoDB; 808912at2759; -.
DR Proteomes; UP000248481; Chromosome 8.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF274; TUBULOINTERSTITIAL NEPHRITIS ANTIGEN; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000248481}.
FT DOMAIN 59..107
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
SQ SEQUENCE 476 AA; 54632 MW; 676719FBC088F830 CRC64;
MWTGCKILIF SYLTTEIWME KQYFSQREVN PGPAFTRNHT VWEGPRFKRA IFKGQYCRSF
GCCEDRDDDC ATHFYEANAL CYCDKFCERE NSDCCPDYKS FCREEKEWPP HTKPWDPEGC
LRDGQPYEEG SVIKENCNSC TCSGQQWKCS QLVCLVQPEL IEHVNKGDYG WTAQNYSQFW
GMTLEEGFSY RLGTLPPNPM LLSMNEMTAS LRETTDLPEF FIASYKWPGW THGPLDQKNC
AASWAFSTAS VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWFLRKRG
LVSHACYPLF KDQNATNYGC AMASRSDGRG KRHATKPCPN NIEKSNRIYQ CSPPYRVSSN
ETEIMKEIMQ NGPVQAIMQV HEDFFHYKTG IYRHVTRTNE ESSKYQKLQT HAVKLTGWGT
LKGAQGQKEK FWIAANSWGK LWGENGYFRI LRGVNESDIE KLIIAAWGHL TSSDEP
//
