ID   A0A2Y9HKA8_NEOSC        Unreviewed;       291 AA.
AC   A0A2Y9HKA8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Claudin-23 {ECO:0000313|RefSeq:XP_021549904.1};
GN   Name=CLDN23 {ECO:0000313|RefSeq:XP_021549904.1};
OS   Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC   Neomonachus.
OX   NCBI_TaxID=29088 {ECO:0000313|Proteomes:UP000248481, ECO:0000313|RefSeq:XP_021549904.1};
RN   [1] {ECO:0000313|RefSeq:XP_021549904.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_021549904.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000256|ARBA:ARBA00004435}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the claudin family.
CC       {ECO:0000256|ARBA:ARBA00008295}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_021549904.1; XM_021694229.2.
DR   AlphaFoldDB; A0A2Y9HKA8; -.
DR   STRING; 29088.A0A2Y9HKA8; -.
DR   KEGG; nsu:110584197; -.
DR   InParanoid; A0A2Y9HKA8; -.
DR   OrthoDB; 3951433at2759; -.
DR   Proteomes; UP000248481; Chromosome 2.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; CLAUDIN; 1.
DR   PANTHER; PTHR12002:SF3; CLAUDIN-23; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01077; CLAUDIN.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248481};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..291
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015976039"
FT   TRANSMEM        79..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        113..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        155..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          190..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  31714 MW;  1AC153491FF5A44D CRC64;
     MRTPVVMTLG MVLAPCGLLL DLTATLAPGW RLVKGFLNQP VDVELYQGLW DMCREQSSRE
     RQCNQPDLWG YFDAEPVRVA RALMVTSLAT TALGLLLASL GVRCWQEKPR FPLAGLSGVV
     LFAAGLLSLV PVSWYNHFLA DRTVLPADAS PVTVHVSYSL VLGYLGSCLL LLGGFSLALS
     LAPWCEGRCR RRRKEPPGSP RRSSISTVHV DWPEPTLPPA IKYYSDGQHR PRPAELGAAR
     KPKAGFPMPR PQPRAFSNQL DVLRGEDARS PGDSLGSTGS CHASLPCDSD L
//