ID A0A2Y9HMN6_NEOSC Unreviewed; 480 AA.
AC A0A2Y9HMN6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Endothelial transcription factor GATA-2 isoform X1 {ECO:0000313|RefSeq:XP_021550760.1};
GN Name=GATA2 {ECO:0000313|RefSeq:XP_021550760.1};
OS Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Neomonachus.
OX NCBI_TaxID=29088 {ECO:0000313|Proteomes:UP000248481, ECO:0000313|RefSeq:XP_021550760.1};
RN [1] {ECO:0000313|RefSeq:XP_021550760.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_021550760.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_021550760.1; XM_021695085.1.
DR AlphaFoldDB; A0A2Y9HMN6; -.
DR STRING; 29088.A0A2Y9HMN6; -.
DR KEGG; nsu:110584900; -.
DR InParanoid; A0A2Y9HMN6; -.
DR OrthoDB; 685518at2759; -.
DR Proteomes; UP000248481; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0051240; P:positive regulation of multicellular organismal process; IEA:UniProt.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 2.
DR InterPro; IPR016374; TF_GATA-2/3.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071:SF149; ENDOTHELIAL TRANSCRIPTION FACTOR GATA-2; 1.
DR PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1.
DR Pfam; PF00320; GATA; 2.
DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248481};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}.
FT DOMAIN 289..343
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT DOMAIN 343..396
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 119..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 50494 MW; 2E2772652777B651 CRC64;
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP
FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVTSLT PTAAHSGSHL FGFPPTPPKE
VSPDPSTAGA ASPASSSAGG SAARGEDKDG VKYQVSLTDS MKMESGSPLR PGLAAMGTQP
ATHHPIPTYP SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM STKSKKNKKG AECFEELSKC
MQEKASPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HHSSMVTAMG
//
