ID A0A2Y9I8J6_NEOSC Unreviewed; 1201 AA.
AC A0A2Y9I8J6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Solute carrier family 12 member 2 isoform X1 {ECO:0000313|RefSeq:XP_021557830.1};
GN Name=SLC12A2 {ECO:0000313|RefSeq:XP_021557830.1};
OS Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae;
OC Neomonachus.
OX NCBI_TaxID=29088 {ECO:0000313|Proteomes:UP000248481, ECO:0000313|RefSeq:XP_021557830.1};
RN [1] {ECO:0000313|RefSeq:XP_021557830.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_021557830.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_021557830.1; XM_021702155.2.
DR AlphaFoldDB; A0A2Y9I8J6; -.
DR STRING; 29088.A0A2Y9I8J6; -.
DR KEGG; nsu:110591279; -.
DR InParanoid; A0A2Y9I8J6; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000248481; Chromosome 7.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248481};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 725..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..242
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 279..781
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 790..1201
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 35..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..977
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1201 AA; 130298 MW; EA4651C479EA6C97 CRC64;
MEPGPTAPSS GAPRLAGVGE TPPAAALAAA GVDLPGTAVP SVSEDAAAAS RGGGGVRGEG
AAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRTAAAGAGA GGKETPADGK ASGESGPGKG
SEEAKGRFRV NFVDPAASSS ADESLSDAAG VGGDGPNVSF QNGGDTVLSE GSSLHSGGGG
GSGHHQHYYY DTHTNTYYLR TFGHNTMDAV PRIDHYRHTA AQLGEKLLRP SLAELHDELE
KEPFEDGFAN GEESTPTRDA VVTYTAESKG VVKFGWIKGV LVRCMLNIWG VMLFIRLSWI
VGQAGIGLSV VVIMMATVVT TITGLSTSAI ATNGFVRGGG AYYLISRSLG PEFGGAIGLI
FAFANAVAVA MYVVGFAETV VELLKEHSIL MIDEINDIRI IGAITVVILL GISVAGMEWE
AKAQIVLLVI LLLAIADFVI GTFIPLDSKK PKGFFGYKSE IFNENFGPDF REEETFFSVF
AIFFPAATGI LAGANISGDL ADPQSAIPKG TLLAILITTV VYIGIAVSVG SCVVRDATGN
VNDTIVTELT NCTSAACKLN FDFSSCESNP CYYGLMNNFQ VMSMVSGFAP LISAGIFSAT
LSSALASLVS APKIFQALCK DNIYPAFQMF AKGYGKNNEP LRGYVLTFLI ALGFILIAEL
NVIAPIISNF FLASYALINF SVFHASLAKS PGWRPAFKYY NMWISLLGAI LCCIVMFVIN
WWAALLTYVI VLGLYIYVTY KKPDVNWGSS TQALTYLSAL QHSIRLSGVE DHVKNFRPQC
LVMTGAPNSR PALLHLVHDF TKNVGLMICS HVHMGPRRQA MKEISIDQAR YQRWLIKNKM
KAFYAPVHAD DLREGAQYLM QAAGLGRMKP NTLVLGFKKD WLQADMRDVD MYINIFHDAF
DIQYGVVVIR LKEGLDISHL QGQEELLSSQ EKSPGVKDVV LSMEYSKKSD LDTSKPSDEK
AVTHKDEEED GKTPTQPLLK KECKGPAVPL NVADQKLLEA STQFQKKQGK NTIDVWWLFD
DGGLTLLIPY LLTTKKKWKD CKIRVFIGGK INRIDHDRRA MATLLSKFRI DFSDIMVLGD
INTKPKKENI VAFDEMIEPY RLHEDDKEQD IADKMKEDEP WRITDNELEL YKTKTYRQIR
LNELLKEHSG TANIIVMSLP VARKGAVSSA LYMAWLEALS KDLPPVLLVR GNHQSVLTFY
S
//
