ID A0A2Y9IE21_ENHLU Unreviewed; 1546 AA.
AC A0A2Y9IE21;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Rho guanine nucleotide exchange factor 11 isoform X4 {ECO:0000313|RefSeq:XP_022346873.1};
GN Name=LOC111139050 {ECO:0000313|RefSeq:XP_022346873.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022346873.1};
RN [1] {ECO:0000313|RefSeq:XP_022346873.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022346873.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_022346873.1; XM_022491165.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13391; PH_PRG; 1.
DR CDD; cd08753; RGS_PDZRhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR037889; PDZRhoGEF_RGS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037803; PRG_PH.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00315; RGS; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 46..110
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 729..918
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 960..1074
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1393..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1099
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1502..1519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1546 AA; 169546 MW; 0B412F226C64848C CRC64;
MSVRLPQSID RLSSLSLGDP APERRSPSHL RQPSDASETA GLVQRCVIIQ KDQHGFGFTV
SGDRIVLVQS VRPGGAAMRA GVKEGDRIIK VNGTMVTNSS HLEVVKLIKS GAYVALTLLG
SSPSPLGVSG LQQDPAPAGT PRATPVVPPP PPPPPLPPPQ RITGPKPLQD PEFQKHATQI
LLNMLRQEEK ELQRICEVYS RNPASPLEEQ IEGARRRVTQ LQLKIQQETG TGGVDVPLQY
GDASQRASEG QLSLDSQEGD SGLDSGTERF PSLNEGTDQS PKPLIIGPEE DYDPGYFNNE
SDSVFQDLEK LKARPAHLAV FLRYIFSQAD PSPLLFYLCT EVYQQTNPKD SRTLGKDIWN
IFLEKNAPLR VKVPEVLQAE IDLRLRASED VRIALREAQE AAMPEIQEQM QDYRAKRTLG
LGSLYGENDL LGLDGDPVRE RQVAEKQLAA LADILSKYEE DRSAPMDFAL NAYMSHAGLR
LREARPSSAA EKAQAAPDRD KWLPFFPKTK KQSSNSKKDK DALEDKRRNP ILKYIGKPKS
SSQSTFHIPL SPVEVKPGNV RNIIQHFENN QPYEAPEPGT QRLSTGSFPE DLLESDSSRS
EIRLGRSESL KGREEMKRSR KAENVPRSRS DVDMDAAAEA ARLHQSASSS ASSLSTRSLE
NPTPPFTPKM GRRSIESPSL GFCTDSLLPH LLEDDLGQLS DLEPEPDAQN WQHTVGKDVV
AGLSQREIDR QEVINELFVT EASHLRTLRV LDLIFYQRMK KENLMPREEL ARLFPNLPEL
IEIHNSWCEA MRKLREEGPI VKDIGDLMLA RFDGPAREEL QQVAAQFCSC QSAALGLIKA
KQRKESRFQL FMQEAESHPQ CRRLQLRDLI ISEMQRLTKY PLLLESVLKH TEGGTPEHEK
LCRARDQCRE ILKYVNEAVK QTENRLRLEG YQKRLDTTSL ERASNPLAAE FKSLDLTARR
MVHEGPLSWR ISKDKTLDLH ALLLEDLLVL PQRQDEKLLL KCHSKTAAGS SDSKQTFSPV
LKLNAVLVRS VATDKRAFFV ICTSELGPPQ IYELVALTSS DKNTWMELLE EAVRNATRRP
GGAPTLAHPP APGPQEPAHQ SPTPSRVQLD GSEVFHSEPE PGELPGAGPG PQQRAKGTHL
VLPEDPEQEG SLEEELGALP HPSTSADGEH RGGRTRDPIL LPLPGPLFME GLADSALEDV
ESLRRLILGS LLQGRRPEAQ PAGEPEDDLT PTPSLGSSTC HPADPGSLGH GLLRGEEPEL
GDAALRSLEQ LPPRARNSGI WESPELDRNP EEEALSAEAA GSYKVVRKAG GGTDAAEVAG
SKARLPESGR SGPEPPDVEG GAEAAGNELP LGTRARPGLE CGACRKGDGG GQRARLRGLT
PACIHRVFPE SIHGGGIAPR DRGSPGPSRE TGWSGVKTVG RPREPGAPSL WRLPFSPQPR
VGQGVCGIPW DPLWPRVSQG VCRIPRKRVV GAGAARTFIS RACNGAGMKE PPCAPVPDQS
PSLPLLQGQG GTPDSPAATT EHPPSAWAIG KALWRRKAFR GDRWAW
//