GenomeNet

Database: UniProt
Entry: A0A2Y9IE21_ENHLU
LinkDB: A0A2Y9IE21_ENHLU
Original site: A0A2Y9IE21_ENHLU 
ID   A0A2Y9IE21_ENHLU        Unreviewed;      1546 AA.
AC   A0A2Y9IE21;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Rho guanine nucleotide exchange factor 11 isoform X4 {ECO:0000313|RefSeq:XP_022346873.1};
GN   Name=LOC111139050 {ECO:0000313|RefSeq:XP_022346873.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022346873.1};
RN   [1] {ECO:0000313|RefSeq:XP_022346873.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022346873.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_022346873.1; XM_022491165.1.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd13391; PH_PRG; 1.
DR   CDD; cd08753; RGS_PDZRhoGEF; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR037889; PDZRhoGEF_RGS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037803; PRG_PH.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR015212; RGS-like_dom.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR45872:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11; 1.
DR   PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   Pfam; PF09128; RGS-like; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00315; RGS; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          46..110
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          729..918
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          960..1074
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1078..1137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1157..1177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1215..1255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1269..1295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1311..1355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1393..1435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1490..1525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..165
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..279
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..532
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..593
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        594..638
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..663
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1085..1099
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1502..1519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1546 AA;  169546 MW;  0B412F226C64848C CRC64;
     MSVRLPQSID RLSSLSLGDP APERRSPSHL RQPSDASETA GLVQRCVIIQ KDQHGFGFTV
     SGDRIVLVQS VRPGGAAMRA GVKEGDRIIK VNGTMVTNSS HLEVVKLIKS GAYVALTLLG
     SSPSPLGVSG LQQDPAPAGT PRATPVVPPP PPPPPLPPPQ RITGPKPLQD PEFQKHATQI
     LLNMLRQEEK ELQRICEVYS RNPASPLEEQ IEGARRRVTQ LQLKIQQETG TGGVDVPLQY
     GDASQRASEG QLSLDSQEGD SGLDSGTERF PSLNEGTDQS PKPLIIGPEE DYDPGYFNNE
     SDSVFQDLEK LKARPAHLAV FLRYIFSQAD PSPLLFYLCT EVYQQTNPKD SRTLGKDIWN
     IFLEKNAPLR VKVPEVLQAE IDLRLRASED VRIALREAQE AAMPEIQEQM QDYRAKRTLG
     LGSLYGENDL LGLDGDPVRE RQVAEKQLAA LADILSKYEE DRSAPMDFAL NAYMSHAGLR
     LREARPSSAA EKAQAAPDRD KWLPFFPKTK KQSSNSKKDK DALEDKRRNP ILKYIGKPKS
     SSQSTFHIPL SPVEVKPGNV RNIIQHFENN QPYEAPEPGT QRLSTGSFPE DLLESDSSRS
     EIRLGRSESL KGREEMKRSR KAENVPRSRS DVDMDAAAEA ARLHQSASSS ASSLSTRSLE
     NPTPPFTPKM GRRSIESPSL GFCTDSLLPH LLEDDLGQLS DLEPEPDAQN WQHTVGKDVV
     AGLSQREIDR QEVINELFVT EASHLRTLRV LDLIFYQRMK KENLMPREEL ARLFPNLPEL
     IEIHNSWCEA MRKLREEGPI VKDIGDLMLA RFDGPAREEL QQVAAQFCSC QSAALGLIKA
     KQRKESRFQL FMQEAESHPQ CRRLQLRDLI ISEMQRLTKY PLLLESVLKH TEGGTPEHEK
     LCRARDQCRE ILKYVNEAVK QTENRLRLEG YQKRLDTTSL ERASNPLAAE FKSLDLTARR
     MVHEGPLSWR ISKDKTLDLH ALLLEDLLVL PQRQDEKLLL KCHSKTAAGS SDSKQTFSPV
     LKLNAVLVRS VATDKRAFFV ICTSELGPPQ IYELVALTSS DKNTWMELLE EAVRNATRRP
     GGAPTLAHPP APGPQEPAHQ SPTPSRVQLD GSEVFHSEPE PGELPGAGPG PQQRAKGTHL
     VLPEDPEQEG SLEEELGALP HPSTSADGEH RGGRTRDPIL LPLPGPLFME GLADSALEDV
     ESLRRLILGS LLQGRRPEAQ PAGEPEDDLT PTPSLGSSTC HPADPGSLGH GLLRGEEPEL
     GDAALRSLEQ LPPRARNSGI WESPELDRNP EEEALSAEAA GSYKVVRKAG GGTDAAEVAG
     SKARLPESGR SGPEPPDVEG GAEAAGNELP LGTRARPGLE CGACRKGDGG GQRARLRGLT
     PACIHRVFPE SIHGGGIAPR DRGSPGPSRE TGWSGVKTVG RPREPGAPSL WRLPFSPQPR
     VGQGVCGIPW DPLWPRVSQG VCRIPRKRVV GAGAARTFIS RACNGAGMKE PPCAPVPDQS
     PSLPLLQGQG GTPDSPAATT EHPPSAWAIG KALWRRKAFR GDRWAW
//
DBGET integrated database retrieval system