ID A0A2Y9IEA4_ENHLU Unreviewed; 550 AA.
AC A0A2Y9IEA4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cochlin {ECO:0000256|ARBA:ARBA00013828};
GN Name=LOC111139099 {ECO:0000313|RefSeq:XP_022346958.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022346958.1};
RN [1] {ECO:0000313|RefSeq:XP_022346958.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022346958.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the control of cell shape and motility in the
CC trabecular meshwork. {ECO:0000256|ARBA:ARBA00003388}.
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DR RefSeq; XP_022346958.1; XM_022491250.1.
DR AlphaFoldDB; A0A2Y9IEA4; -.
DR STRING; 391180.A0A2Y9IEA4; -.
DR KEGG; elk:111139099; -.
DR OrthoDB; 2883115at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR CDD; cd01472; vWA_collagen; 1.
DR CDD; cd01482; vWA_collagen_alphaI-XII-like; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020:SF36; COCHLIN; 1.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR Pfam; PF03815; LCCL; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00603; LCCL; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..550
FT /note="Cochlin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015992618"
FT DOMAIN 28..121
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 165..350
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 367..537
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 126..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 59574 MW; C4235E5F05767D1B CRC64;
MSAAWIPVLC LGVCLLLLPE PAGSEGAVPI AITCFTRGLD IRKEKADVLC PGGCALEEFS
VFGNIVYASV SSICGAAVHR GVISNSGGPV RIYSLPGREN YSSVAANGIQ SQTLSRWSAS
FTVTKGKSGT QEATGQAVST ARPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR
FNLQKNFVGK VALMLGIGTE GPHVGLVQAS EHPKIEFYLK NFTSAKDVLF AIKEVGFRGG
NSNTGKALKH TAQKFFTADT GVRKGIPKVV VVFIDGWPSD DIEEAGIVAR EFGVNVFIVS
VAKPIPEELG MVQDVAFVDK AVCRNNGFFS YHMPNWFGTT KYVKPLVQKL CTHEQMMCSK
TCYNSVNIAF LIDGSSSVGD SNFRLMLEFV SNIAKTFEIS DIGAKIAAVQ FTYDQRTEFS
FTDYSTKENI LAVIRNIRYM SGGTATGEAI SFTVRNVFGP VRDSPNKNFL VIVTDGQSYD
DVRGPAAAAH DTGITIFSVG VAWAPLDDLK DMASKPKESH AFFTREFTGL EPIVSDVIRG
ICRDFLESQQ
//
