ID A0A2Y9IEK2_ENHLU Unreviewed; 757 AA.
AC A0A2Y9IEK2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Kin of IRRE-like protein 1 isoform X2 {ECO:0000313|RefSeq:XP_022346796.1};
GN Name=LOC111139008 {ECO:0000313|RefSeq:XP_022346796.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022346796.1};
RN [1] {ECO:0000313|RefSeq:XP_022346796.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022346796.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC {ECO:0000256|ARBA:ARBA00008637}.
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DR RefSeq; XP_022346796.1; XM_022491088.1.
DR AlphaFoldDB; A0A2Y9IEK2; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05759; IgI_2_KIRREL3-like; 1.
DR CDD; cd05898; IgI_5_KIRREL3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF14; KIN OF IRRE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..757
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016127620"
FT TRANSMEM 495..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..115
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 120..216
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 223..299
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 308..373
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 392..488
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 654..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 83227 MW; CAD526F46B7D0198 CRC64;
MLSLLVWILT LSDTFSQGTQ TRFSQEPADQ TVVAGQRAVL PCVLLNYSGI VQWTKDGLAL
GMGQGLKAWP RYRVVGSADA GQYNLEITDA ELSDDASYEC QATEAALRSR RAKLTVLIPP
EDTRIDGGPV ILLQAGTPHN LTCRAFNAKP AATIIWFRDG TQQEGAVAST ELLKDGKRET
TISRLLINPT DLDIGRVFTC RSVNEATPTG KETSIELDVH HPPTVTLSIE PQTVQEGERV
IFTCQATANP EILGYRWAKG GFLIEDAHES RYETNVDYSF FTEPVSCEVH NKVGSTNVST
LVNVHFAPRI VVDPKPTTTD IGSDVTLTCV WVGNPPLTLT WTKKDSNMVL SNSNQLLLKS
VTQADAGTYT CRAIVPRIGV AEREVPLYVN GPPIISSEAV QYAVRGDGGK VECFIGSTPP
PDRIAWAWKE NFLEAGTLER YTVERTNSGS GVLSTLTINN VMEADFQTHY NCTAWNSFGP
GTAIIQLEER EVLPVGIIAG ATIGAGVLLT FFFIALVFFL YRRRKGSRKD VTLRKLDIKV
ETVNREPLTM HSDREDDTAS VSTATRVMKA IYSSFKDDVD LKQDLRCEAM DTREEYEMKD
PTNGYYNVRA HEDRPASRAV LYADYRAPGP ARFDGRPASR LSHSSGYAQL SSYSRAPASD
FGPDPAAPGP AAPAGADSAS TLSYENYDKF NPHPFPAAAG YPTYRLGYPQ APPSGLERTP
FEAYDPIGKY ATATRFSYTS QHSDYGQRFQ QRMQTHV
//
