ID A0A2Y9IG32_ENHLU Unreviewed; 513 AA.
AC A0A2Y9IG32;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Zinc finger protein 331 isoform X1 {ECO:0000313|RefSeq:XP_022347568.1};
GN Name=LOC111139552 {ECO:0000313|RefSeq:XP_022347568.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022347568.1};
RN [1] {ECO:0000313|RefSeq:XP_022347568.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022347568.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022347568.1; XM_022491860.1.
DR AlphaFoldDB; A0A2Y9IG32; -.
DR STRING; 391180.A0A2Y9IG32; -.
DR KEGG; elk:111139552; -.
DR OrthoDB; 3120634at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR47772:SF4; REDUCED EXPRESSION 2-RELATED; 1.
DR PANTHER; PTHR47772; ZINC FINGER PROTEIN 200; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 79..168
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 205..232
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 233..260
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 261..288
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 289..316
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 317..344
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 345..372
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 373..400
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 401..428
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 429..456
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 457..484
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 485..512
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 513 AA; 58177 MW; EE69EE4C615493E2 CRC64;
MGSCLLTAWG DEVLCRVCAF SAAAGSSGAL GALLCPSLHC ALYTSQACGL LLCPAQPRAE
PSLCCPSQGR VGLCFQGLVT FSDVAINFSQ EEWACLDSSQ RDLYWDVMLE NYSNLVSLDL
ESPYGTKSLP TEKGLYEINL SKWNSNGKSK SLGLDWMCEG ECEGPRGPQE GCFNQMIINC
EKTPTCRENT SVRPHQRLHT RENSYECKEC GKAFSRGYQL TQHQKIHTGE KPYECKECKK
AFRWGNQLTQ HQKIHTGEKP YECKDCGKAF RWGSSLVIHK RIHTGEKPYE CKDCGKAFRR
GDELTQHQRF HTGEKDYECK DCGKTFSRVY KLIQHKRIHS GEKPYECKDC GKAFICGSSL
VQHKRIHTGE KPYECQECGK AFTRVNYLTQ HQKIHTGEKP HECKECGKAF RWGSSLVKHE
RIHTGEKPYK CTECGKAFNC GYHLTQHERI HTGETPYKCK ECGKAFIYGS SLVKHERIHT
GEKPYECKEC GKAFSHGHQL TQHQKIHTGE KSF
//
