ID A0A2Y9IGG5_ENHLU Unreviewed; 480 AA.
AC A0A2Y9IGG5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q8 alpha chain-like {ECO:0000313|RefSeq:XP_022347698.1};
GN Name=LOC111139664 {ECO:0000313|RefSeq:XP_022347698.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022347698.1};
RN [1] {ECO:0000313|RefSeq:XP_022347698.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022347698.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|RuleBase:RU004439}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022347698.1; XM_022491990.1.
DR AlphaFoldDB; A0A2Y9IGG5; -.
DR STRING; 391180.A0A2Y9IGG5; -.
DR KEGG; elk:111139664; -.
DR OrthoDB; 3840485at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd07698; IgC1_MHC_I_alpha3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF134; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..480
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015958395"
FT TRANSMEM 433..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 337..425
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 313..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 54413 MW; 5532EBA466B14812 CRC64;
MLLLLQLWRL LPESAAVLIL LTLLPEPDLI LDFPTAALGP RPPVTQMLES LSAQTGNPWG
LPVVADGPAS LAKMVMAELT NLKLENKPWP GGTHSLHYHY LALSEPGPDL PQFLAVGYVD
DQPFIHYDSR VDRAKPQAPW MATVDAQYWE TETQKQRAWA KVQLVETWTV MGYHNQSTGM
HSTQRMFGCE IREDGHTHSF WQFGFDGQDH LSLDLETLNW VSAKPAAMRT KSWWETERCY
AEYDKAYLEG LCLVSLRRYL ELGGQSLTRK GISTDTEPNR MWRERVKELA HVTIEDREFQ
DLQLASRRPR RASVSVSVHR QEKTDVPAAG DQAGEPPMVQ VTRHTDPDGC ITLKCWARGF
YPRDISLSWW LGEEELVLET EYVETRPSGD GTYQMWAAVQ VPARTEDQYT CHVQHSGLNH
TLTVTWEAPP RQWITSAVVI PIFIFLLLTA GVLIFIKQYS QGGEDPPVSP VRVEAAQLLC
//
